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Nihon Arukoru Yakubutsu Igakkai Zasshi 1998 Jun;33(3):171-180
[Alcoholic liver disease: new aspects of studies].
[Article in Japanese]
Tsutsumi M, Takase S
Department of Internal medicine, Kanazawa Medical University, Ishikawa, Japan.
Although many factors related to the pathogenesis of alcoholic liver disease
have been considered, 1) hepatotoxic effects of ethanol and its metabolites,
2) effects of excessive hepatic NADH generation, 3) hypoxia, 4) alterations
of the immune system, 5) genetic factors, and 6) nutritional factors may play
more important roles to produce alcoholic liver disease. Recently, genetic polymorphism
of key enzymes related to metabolism of ethanol and acetaldehyde, alcohol dehydrogenase,
cytochrome P4502E1 and aldehyde dehydrogenase, have been discovered. On the
other hand, an assay system for hepatitis C virus (HCV) markers has been developed
and a high frequency of HCV markers in alcoholics with liver disease has been
reported. In this review, we focus on recent gains in our knowledge of pathogenesis
of alcoholic liver disease, and discuss the relationship between alcoholic liver
disease and HCV, and treatment of alcoholic liver disease.
PMID: 9701994, UI: 98367316
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