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Frequencies of the Variant Syndromes in Autoimmune Chronic Liver Disease

table  4.   Results of Corticosteroid Therapy
Treatment Results AIH + PBC (n = 12) AIH + PSC (n = 9) Autoimmune Cholangitis (n = 6) Definite AIH (n = 86)
Remission 9 (75)§,  2 (22) ,¶¶ 0 (0),§ 55 (64),¶¶
Relapse 9/9 (100) 2/2 (100) 0 (0) 41/55 (74)
Sustained remission 0/9 (0) 0/2 (0) 0 (0) 14/55 (25)
Treatment failure 0 (0) 3 (33) 1 (17) 9 (10)
Incomplete responseparallel parallel  parallel 2 (17) 4 (44)** 0 (0) 10 (12)**
Liver-related death or liver transplantation 1 (8) 3 (33) 2 (33) 7 (8)
Poor result¶¶¶ 2 (17) 7 (78)*,,## 1 (17)## 19 (22)*
Developed cirrhosis 0/8 (0)§§§,*** 2/3 (67)§§§ 0 (0) 18/43 (42)***
Prednisone alone 8 (67)dagger dagger 4 (44) 5 (83) 25 (29)¶,dagger dagger
Prednisone and azathioprine 4 (33)dagger dagger 5 (56) 1 (17)# 61 (71)#,dagger dagger
Duration of treatment (mo) 47 ± 16 28 ± 14 3 ± 1 24 ± 4
Duration of follow-up (mo) 114 ± 22dagger 62 ± 38 3 ± 1dagger ,§§ 94 ± 10§§
NOTE. Numbers in parentheses are percentages.
Abbreviation: AIH, autoimmune hepatitis.
Significantly different from each other at levels of *P = .001, ,P = .003, §,P = .009, ¶,#P = .01, ** ,,,§§P = .02,  ,¶¶P = .03, ##,*** ,P = .04, and    ,§§§P = .05.
parallel   parallel   parallel Incomplete response connotes the absence of a treatment end point after at least 6 months of therapy. Patients treated for shorter durations were not included.
¶¶¶ Poor result includes treatment failure and incomplete response. Death from hepatic failure and/or liver transplantation was not included as a poor result unless it occurred during immediate therapy and was categorized as a treatment failure.

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