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Frequency and Nature of the Variant Syndromes of Autoimmune Liver Disease

table  5.   Features Associated With Corticosteroid Responses in the Variant Syndromes
Features Corticosteroid Responses
Remission (n = 11) Treatment Failure (n = 4) Poor Response (n = 10)
AST (reference value, 31 U/L) 699 ± 203 520 ± 309 372 ± 162
Bilirubin (reference value, 1.1 mg/dL) 4.9 ± 1.4 5.5 ± 3.1 5.7 ± 2.6
Alkaline phosphatase (reference value, 309 U/L) 276 ± 53 881 ± 339 786 ± 174
Alkaline phosphatase 2× reference value  0 (0)* 2 (50) 5 (50)
 -Globulin (reference value, 0.7-1.7 g/dL) 3.6 ± 0.2Dagger 2.9 ± 0.5 2.7 ± 0.3
 -Globulin 2× reference value  6 (54) 1/3 (33) 3 (30)
Immunoglobulin G (reference value, 700-1500 mg/dL) 3134 ± 314§ 2998 ± 713 2596 ± 357
Immunoglobulin G 2× reference value  6 (54) 2 (50) 4 (40)
SMA 1:40 10 (91) 3 (75) 6 (67)
ANA 1:40  5 (45) 3 (75) 6 (60)
DR4+  5 (45) 2 (50) 4 (40)
Autoimmune score 16 ± 1 16 ± 2 16 ± 1
Aggregate scores >15  5 (45) 2 (50) 5 (50)
NOTE. Numbers in parentheses are percentages.
Abbreviation: AST, serum aspartate aminotransferase level.
Significantly different from those without the response at levels of *,Dagger P = .001, P = .004, and §P = .04.

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