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Effects of Propranolol on the Hepatic Hemodynamic Response to Physical Exercise
in Patients With Cirrhosis
| table 2. Splanchnic Hemodynamics in
Baseline Conditions, After Placebo or Propranolol Administration,
During Exercise and 30 Minutes After Recovery Period |
|
|
Placebo or Propranolol
Infusion
|
| Baseline |
Pre-exercise |
Exercise |
Recovery |
ANOVA |
|
| HVPG (mm Hg) |
|
|
|
|
| Placebo |
16.9 ± 0.9 |
16.7 ± 0.9 |
19.0 ± 1.0 |
16.7 ± 0.8 |
0.04 |
| Propranolol |
19.3 ± 1.1 |
16.3 ± 1.0* |
12.9 ± 1.1*, |
16.9 ± 1.2* |
0.002 |
HBF (mL · min 1) |
|
| Placebo |
1,074 ± 119 |
990 ± 141 |
810 ± 72* |
843 ± 82 |
0.05 |
| Propranolol |
1,366 ± 123 |
978 ± 104* |
724 ± 79*, |
926 ± 91* |
0.001 |
| EHVR (dyn · s · cm5) |
| Placebo |
1,320 ± 107 |
1,481 ± 172 |
1,895 ± 116*, |
1,612 ± 125 |
0.03 |
| Propranolol |
1,191 ± 131 |
1,433 ± 151 |
1,623 ± 178 |
1,444 ± 109 |
ns |
| AzBF (mL · min1)§ |
| Placebo |
537 ± 64 |
522 ± 75 |
547 ± 70 |
504 ± 54 |
ns |
| Propranolol |
722 ± 117 |
396 ± 64* |
398 ± 42* |
383 ± 59* |
0.02 |
|
NOTE. Data are shown as means ± SEM.
Abbreviations: EHVR, estimated hepatic vascular resistance; ns, not
significant.
* P < .05 vs.
baseline.
.gif) P < .05 vs. pre-exercise.
 Measured in 10 patients
in each group.
§ Measured in 6 patients
in each group. |
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