Hepatitis Central

The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatments.

Effects of Propranolol on the Hepatic Hemodynamic Response to Physical Exercise in Patients With Cirrhosis
table 3. Systemic Hemodynamics in Baseline Conditions, After Placebo or Propranolol Administration, During Exercise and 30 Minutes After Recovery Period
Placebo or Propranolol Infusion
Baseline Pre-exercise Exercise Recovery ANOVA
HR (beats · min1)
  Placebo 81 ± 5 78 ± 5 119 ± 5*,dagger 84 ± 5 0.000
  Propranolol 83 ± 2 66 ± 1* 100 ± 2*,dagger 72 ± 2* 0.000
MAP (mm Hg)
  Placebo 99 ± 4 96 ± 4 126 ± 11*, dagger 95 ± 4 0.003
  Propranolol 100 ± 4 98 ± 4 113 ± 4*,dagger 90 ± 6* 0.01
CO (L · min1)Dagger
  Placebo 9.9 ± 0.8 9.7 ± 1.0 17.6 ± 0.5*, dagger 9.0 ± 2.0 0.004
  Propranolol 8.2 ± 0.6 6.2 ± 0.5* 11.1 ± 0.8*, dagger 5.9 ± 0.5* 0.000
SV (mL)Dagger
  Placebo 105 ± 8 103 ± 9 148 ± 6*, dagger 90 ± 7 0.03
  Propranolol 98 ± 8 93 ± 8 110 ± 7 81 ± 6 ns
SVR (dyn · s · cm5)Dagger
  Placebo 842 ± 113 807 ± 106 464 ± 51*, dagger 887 ± 298 0.05
  Propranolol 1,022 ± 96 1,329 ± 139 770 ± 83*, dagger 1,215 ± 161 0.02
PAP (mm Hg)Dagger
  Placebo 13.0 ± 2.3 12.3 ± 2.7 27.5 ± 6.1*, dagger 10.0 ± 2.0 0.05
  Propranolol 13.6 ± 1.2 16.5 ± 1.4 38.7 ± 2.8*, dagger 14.1 ± 1.7 0.000
PCP (mm Hg)Dagger
  Placebo 6.7 ± 1.2 6.0 ± 2.6 18.8 ± 5.1*,dagger 3.3 ± 0.3 0.05
  Propranolol 7.6 ± 0.5 11.4 ± 0.8 30.0 ± 2.4*,dagger 7.9 ± 1.0 0.000
RAP (mm Hg)Dagger
  Placebo 3.2 ± 0.8 3.7 ± 1.4 8.2 ± 2.0 6.3 ± 3.3 ns
  Propranolol 4.7 ± 0.7 6.6 ± 0.9 16.4 ± 2.6*, <dagger 7.5 ± 2.6* 0.001
PVR (dyn · s · cm5)Dagger
  Placebo 52 ± 6 55 ± 8 40 ± 9 67 ± 31 ns
  Propranolol 59 ± 9 67 ± 11 72 ± 15 84 ± 11 ns
NOTE. Data are shown as means ± SEM.
Abbreviations: SV, stroke volume; SVR, systemic vascular resistance; PAP, mean pulmonary artery pressure; PCP, wedged pulmonary capillary pressure; RAP, right atrial pressure; PVR, pulmonary vascular resistance; ns, not significant.
* P < .05 vs. baseline.
dagger P < .05 vs. pre-exercise.
Dagger Measured in 5 patients in placebo group and in 6 patients in propranolol group.

Return To Article

Site Topics

  • Frequently Asked Questions

    Some of our most commonly asked questions and our answers to them.

  • HCV Symptoms

    You'll find links to a comprehensive symptoms list, as well as various studies and discussions about Hepatitis C symptoms.

  • Lab Tests

    What they are and what they mean. Helps you interpret & understand all the various hepatitis lab tests likely to be encountered.

  • Hepatitis C Genotypes

    Learn about Hepatitis C Genotypes and their variants.

  • Viral Load

    Provides detailed information on how to analyze and interpret viral load numbers as well as a link to a convenient Viral Load Chart.

  • What is...?

    Learn more about various Hepatitis C related topics, including HCV, Ascites, Biopsies, and much more.

  • HCV Medicines

    Numerous links to studies, info sheets, FAQs, and analysis of Ribavirin/Rebetron medicines.

  • Glossary

    Commonly used medical terms and definitions.

  • Hepatitis C Doctors

    A state-by-state and worldwide reference listing physicians who treat HCV, including an email link to submit your physician for inclusion.

  • Biopsy Info

    A comprehensive resource of information relating to the liver biopsy.

  • Cirrhosis

    Many discussions and analyses of cirrhosis, including causes, complications, pathology, symptoms, and much more.

  • Liver Cancer

    Liver Cancer/Hepatocellular Carcinoma studies, info sheets, FAQs, and analysis.

  • Liver Disease Medicines

    An exhaustive list of links to studies, info sheets, FAQs, and analysis of the various drugs used to treat liver disease.

  • Hep-Central Email List

    Sign up to learn about advances and breakthroughs in Hepatitis C research, including information about medical and complementary treatments.

  • HCV Links

    Convenient links to other sites external to Hepatitis-Central.

  • HCV Transmission

    Information about the transmission of Hepatitis C.

  • HCV Natural Remedies

    A number of herbal products useful in the management of liver disease.

  • HCV Books

    Recommended reading for those interested in hepatitis information.

  • Hepatitis C Forum

    A Bulletin Board for discussions on hepatitis, treatments, etc.

  • Hepatitis C Activism

    An easy way to get involved in urging our government to do more for Hepatitis C awareness and treatment research.

Advertisement(s)

Advertisement