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Cryoglobulinemia can be associated with several infections, immunoproliferative
tumors, chronic liver, renal and systemic autoimmune diseases
Z Gastroenterol 1998 May;36(5):391-401
[No title available]. [Article in German]
Csepregi A, Nemesanszky E, Bely M Abt. fur Gastroenterologie und Innere
Medizin, Landesinstitut fur Rheumatologie und Physiotherapie, Budapest, Ungarn.
[Medline record in process]
Cryoglobulinemia can be associated with several infections, immunoproliferative
tumors, chronic liver, renal and systemic autoimmune diseases. In the first
part of the publication the authors give a review of the main clinical and laboratory
properties of cryoglobulins. In essential mixed cryoglobulinemia syndrome (purpura,
arthralgia, weakness) clinical and laboratory signs of damaged liver function
can often be seen. However, there are mixed cryoglobulins in chronic liver disease
of different etiologies as well. In 30-94% of patients with hepatitis C virus
infection and hepatitis C virus-induced chronic liver diseases laboratory signs
(occassionally clinical symptoms as well) or mixed cryoglobulinemia can be diagnosed.
Serological markers of hepatitis C virus infection have been found in the cryoprecipitates
of patients with mixed cryoglobulinemia. A high prevalence of mixed cryoglobulins
in serum of patients with chronic hepatitis C virus infection and hepatitis
C virus-induced chronic liver disease suggests that this virus has a significant
role in the pathogenesis of mixed cryoglobulins. Also, an impaired clearance
function of the liver in the uptake of cryo(immuno)complexes may be an important
causative factor in the production of cryoglobulins in chronic liver diseases
of different etiologies.
PMID: 9654707, UI: 98318776
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