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Association of Diabetes Mellitus and Chronic Hepatitis C Virus Infection

table  1.   Characteristics of All Patients in the Chronic Viral Hepatitis Cohort


Clinical Features Virological Diagnosis (%)
P
HBV* (N = 486) HCV* (N = 604)

Age (yr)dagger
  less than37 106 (28) 88 (15) <.0001
  37-43 68 (18) 122 (21)
  43-49 74 (19.5) 117 (20)
  49-61 74 (19.5) 120 (20)
  >61 57 (15) 135 (23)
Sex
  Female 108 (22) 218 (36) <.0001
  Male 375 (78) 386 (64)
Race origindagger
  White 301 (70) 481 (81) <.0001
  African 82 (19) 93 (16)
  Hispanic 7 (2) 10 (2)
  Asian 38 (9) 6 (1)
CirrhosisDagger 88 (38) 145 (41) .51
NoncirrhoticDagger 144 (62) 212 (59)
Study criteria
  (i) Exclusion 87 (18) 109 (18) 1.0
  (ii) Diabetes 64 (13) 145 (24) <.0001
  (iii) Diabetics excluded 16 (18) 37 (34) .015

NOTE. (i) Conditions predisposing to hyperglycemia: hemochromatosis (n = 3), chronic pancreatitis (n = 2), carcinoma of pancreas (n = 1), total parenteral nutrition (n = 6), corticosteroid (n = 179), and hydrochlorothiazide therapy (n = 10). (ii) Use of oral hypoglycemic medication or insulin, random glucose greater than200 mg/dL, fasting glucose greater than140 mg/dL on two occasions, or attending an endocrine clinic for diabetes.
(iii) Diabetics excluded from final analysis (% = patients in [iii] divided by [i] × 100).
* Twenty-seven patients with both chronic HBV and HCV infection were omitted from this table .
dagger gif The discrepancy in numbers compared with total population size is due to records without data.
Dagger Cirrhosis established by liver biopsy (n = 207) or presumptive diagnosis made on clinical grounds (n = 35) and diagnosis of noncirrhotic by liver biopsy (n = 367).

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