Relationship of the Genomic Complexity of Hepatitis C Virus With Liver Disease
Severity and Response to Interferon in Patients With Chronic HCV Genotype 1b
Infection
| table 1. Basal
Features and Complexity of the HVR1, as Determined by SSCP Analysis,
in Patients With Genotype 1b HCV Chronic Infection According to the
Severity of the Underlying Liver Disease |
|
|
Chronic Hepatitis
|
Hepatic Cirrhosis
|
| Mild (n = 41) |
Moderate (n = 45) |
Severe (n = 28) |
Compensated (n = 17) |
Decompensated (n = 17) |
With HCC (n = 20) |
|
| Age (years) |
41.3 ± 12.7 |
47.6 ± 10.6 |
51 ± 10 |
51.9 ± 10.4 |
67.2 ± 6.4 |
65.5 ± 7.9 |
| Sex (M/F) |
23/18 |
26/19 |
21/7 |
10/7 |
10/7 |
12/8 |
| Source of infection |
| Blood transfusion |
13 (31.7%) |
15 (33.3%) |
10 (35.7%) |
6 (35.3%) |
4 (23.5%) |
11 (55%) |
| I.V. drug abuse |
4 (9.8%) |
3 (6.7%) |
2 (7.1%) |
0 |
0 |
2 (10%) |
| Unknown |
24 (58.5%) |
27 (60%) |
16 (57.1%) |
11 (64.7%) |
13 (76.5%) |
7 (35%) |
| AST (IU/L) |
63.7 ± 43.6 |
108.8 ± 73.3 |
100.9 ± 47.9 |
137.6 ± 75.7 |
106.8 ± 51.2 |
110.5 ± 51.4 |
| ALT (IU/L) |
115.5 ± 62.9 |
190.1 ± 131.2 |
173.0 ± 113.7 |
209.5 ± 123.2 |
125.7 ± 87.6 |
106.4 ± 57.4 |
| HCV-RNA (copies × 103/mL) |
239 ± 282 |
433 ± 677 |
380 ± 309 |
417 ± 437 |
346 ± 349 |
475 ± 49 |
| Number of SSCP bands |
8.1 ± 3.9 |
8.0 ± 3.3 |
9.2 ± 3.3 |
8.0 ± 2.9 |
6.3 ± 2.9 |
9.5 ± 2.9 |
| High complexity of quasispecies |
14 (34.1%) |
17 (37.8%) |
14 (50%) |
6 (35.3%) |
3 (17.6%) |
11 (55%) |
| Low complexity of quasispecies |
27 (65.9%) |
28 (62.2%) |
14 (50%) |
11 (64.7%) |
14 (82.4%) |
9 (45%) |
|
NOTE. Quantitative data are expressed as means ± SD.
Numbers in parenthesis represent percentages.
Complexity of quasispecies was defined as low (8 bands or less)
or high (more than 8 bands), according to the median value of
the number of bands in the SSCP analysis.
Abbreviations: HCC, hepatocellular carcinoma. |
|
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Copyright © 1999 by the American Association for the Study of Liver
Diseases.
|
