Relationship of the Genomic Complexity of Hepatitis C Virus With Liver Disease
Severity and Response to Interferon in Patients With Chronic HCV Genotype 1b
Infection
| table 2. Basal
Features and Complexity of the HVR1, as Determined by SSCP Analysis,
in Patients With Genotype 1b HCV Chronic Infection According to the
Response to a Course of Interferon Therapy |
|
|
Sustained
Response
(n = 12) |
Transient
Response
(n = 41) |
No
Response
(n = 69) |
|
| Age (years) |
41.1 ± 13.0 |
46.4 ± 11.7 |
48.8 ± 11.4 |
| Sex (M/F) |
7/5 |
22/19 |
44/25 |
| Source of infection |
| Blood transfusion |
4 (33.3%) |
11 (26.8%) |
22 (31.9%) |
| I.V. drug abuse |
3 (25%) |
2 (4.9%) |
4 (5.8%) |
| Unknown |
5 (41.7%) |
28 (68.3%) |
43 (62.3%) |
| AST (IU/L) |
87.8 ± 60.8 |
80.0 ± 52.5 |
109.1 ± 69.3 |
| ALT (IU/L) |
190.6 ± 138.1 |
142.6 ± 85.8 |
166.5 ± 114.6 |
| HCV-RNA (copies × 103/mL) |
25 ± 35* |
346 ± 388 |
415 ± 506 |
| Number of SSCP bands |
7.5 ± 3.9 |
8.3 ± 2.9 |
8.2 ± 3.6 |
| High complexity of quasispecies |
4 (33.3%) |
16 (39%) |
26 (37.6%) |
| Low complexity of quasispecies |
8 (66.7%) |
25 (61%) |
43 (62.4%) |
|
NOTE. Quantitative data are expressed
as means ± SD. Numbers in parenthesis represent percentages.
Complexity of quasispecies was defined as low (8 bands or less)
or high (more than 8 bands), according to the median value of
the number of bands in the SSCP analysis.
* Significantly different (P = .04)
from transient responders and nonresponders by ANOVA. |
|
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Copyright © 1999 by the American Association for the Study of Liver Diseases.
|
