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Hep C and Fatty Liver Disease Linked by Enzyme
Pittsburgh researchers have found that an enzyme known to participate in fat production is elevated in those with Hepatitis C. Further exploration of this enzyme could help physicians better predict which HCV patients are at risk of developing fatty liver...
ANA773 Resumes Race Against Hepatitis C
By reducing the dosing schedule in half, Anadys Pharmaceuticals returns to their investigation of ANA773, a Toll-Like Receptor-7 agonist prodrug. Approaching the Hepatitis C virus differently from most other contenders, Phase I clinical trials evaluating the safety, tolerability and viral-load...
Popular Illegal Drug Extra Harmful with HCV
Although scores of Americans are turning to the street drug methamphetamine to keep them awake and thin, scientists have found that it worsens Hepatitis C infection in two worrisome ways....
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- D5
- Abbreviation for dextrose (glucose)
given in a 5 percent normal saline solution
- d--Deci
- 1/10g. Decigram (dg)
is a measure of weight; deciliter (dl) is a measure of volume
- DALM
- Dysplasia Associated
Lesion or Mass
- Damiana
- History of use as
an aphrodisiac, supposedly able to stimulate the libido of men and women. Said
to possess mild sedative qualities, able to induce a state of relaxation and
to aid in falling asleep. Often used to treat asthma, bladder infection, diabetes,
impotence, and sterility
- Dandelion
- Taraxacum
officinale. Also known as Blowball, Cankerwort, Lion's tooth, Priest's crown,
Puffball, Swine snout, White endive, and Wild endive. Dandelion plant
comes from the Asteraceae family and has a base of toothy leaves that rises
from a thin, hollow stem and is capped by a deep yellow head of ligulate flowers.
Has two particularly important uses: Promotes the formation of bile and removes
excess water from the body in edemous conditions resulting from liver problems.
Infusion of the fresh root is said to be good for gallstones,
jaundice,
and other liver problems. Also used to treat chronic rheumatism, gout, and stiff
joints
- Darvocet
- Drug (propoxyphene
hydrochloride) prescribed for pain
- DAT
- Diet As Tolerated
- Data
- (pl. of datum) Factual
information, such as measurements, observations, or statistics, which is used
as a basis for reasoning, discussion, or calculation
- Data Collection Visit
- Any
visit by a patient to a study clinic that is used for data collection in the
trial
- Data Dredging
- A term used
to characterize analysis that are done on an ad hoc basis, without benefit of
prestated hypotheses
- Data Editing
- The process of
reviewing data for the purpose of detecting deficiencies or errors in the way
they are collected or recorded. The process of detecting deficient or erroneous
values on completed data forms
- Data Interval
- Data classified
into equal intervals without an absolute zero point, e.g., IQ of 120 is 60 points
higher than an IQ of 60, but this does not necessarily indicate twice as much
intelligence
- Data Nominal
- Data classified
into unordered categories, e.g., male/female, diabetes/no diabetes, mammogram-yes/mammogram-no
- Data, Ordinal
- Data classified
into ordered categories, e.g., intensity of pain (+/++/+++/++++), severity of
disease (mild/moderate/severe/fatal)
- Data & Safety Monitoring Board-DSMB
- A
standing committee responsible for periodically reviewing accumulated data for
evidence of adverse or beneficial treatment effects during the trial and for
initiating recommendations for modification of a study treatment, including
termination of the treatment when appropriate. One of the key committees in
the organizational structure of a multicenter trial. Usually composed primarily,
if not exclusively, of individuals not directly involved in patient care or
data collection in the trial
- Database
- A collection of data
files that are organized in a specified manner, and used in analysis of trials
- Datum
- Singular of data
- DB
- Direct Bilirubin.
Dead Body
- DBP
- Vitamin D-binding protein
- DBW
- Desirable Body Weight
- DC
- Duodenal Cap, Descending
Colon, Dilation Catheter, Discontinuation of treatment
- D&C
- Dilation and Curettage
- DD
- Digestive Disorder
- DE
- Duodenal Exclusion
- Death
- When all vital phenomena
ceases to existbwithout capability of resuscitation, Expired
- Death Receptor
- Death receptors
detect the presence of extracellular death signals and, in response, they rapidly
ignite the cell's intrinsic apoptosis machinery
- Debridement
- Cleaning an open
wound by removing foreign material and dead tissue
- -Deca
- Preferences meaning
ten times, as in decagram, or ten grams
- -Deci
- Prefix meaning one tenth,
as in decigram, or a tenth of a gram
- Deciliter
- One-tenth of a liter;
abbreviation: dl
- Decompensated Liver Disease
- Liver
disease in which the liver is damaged and not functioning normally
- Decompensation
- Failure of
compensation, as of the circulation or heart
- Decompression, Surgical
- Surgery
performed to relieve the pressure compromising function of an organ
- Deep Vein Thrombosis
- A blood
clot in a deep vein
- Defibrillation
- The cessation
of fibrillation of the cardiac muscle and restoration of a normal rhythm
- Deficiency
- State or condition
of lacking a substance, quality or characteristic that is essential for completion.
Deletion
- Deficit
- Shortfall or Lack
- Definitive Host
- The host in
which a parasite reproduces sexually
- Defluxion
- Discharge or flowing
of fluid matter, as from the nose in catarrh; sometimes used synonymously with
inflammation
- Deform
- Shapeless, Disfigure
- Defunct
- Deceased, Dead, Depart,
Finish
- Degenerate
- Deteriorate, Worsens,
To fall off from the normal quality
- Degerneration
- Deterioration;
change from a higher to lower form, especially as in change to less functional
or healthy tissue. Deterioration or worsening of a structure or condition
- Degenerative
- Worsening
- Degradation
- Break-down
- Degraded Liver
- A human liver
divided into many lobes
- Dehydration
- Loss of fluids
from the body, often caused by diarrhea. May result in loss of important salts
and minerals
- Dehydroascorbate
- Oxidized
form of ascorbic acid (vitamin C)
- Delayed Type Hypersensitivity-DTH
- A
cell-mediated immune response that produces a cellular infiltrate and edema
(swelling), redness and induration (hardness) between 48 and 72 hours after
exposure to an antigen
- Delirium
- Mental disturbance
marked by illusions, hallucinations, physical restlessness and inability to
make sense. Usually results from a toxic state and lasts a short time
- Delta Agent
- Previously Hepatitis
D Virus -- single-stranded circular RNA virus of animals; dependent on hepatitis
B virus replication for its expression; involved in chronic liver disease
- Delta Infection
- Infection with
hepatitis
delta virus, occurring either simultaneously with or as a superinfection
in hepatitis B, whose severity it may increase
- Delusional
- Having an irrational
belief that cannot be changed by a rational argument, often found in schizophrenia
and manic-depressive psychosis
- Demarcate
- To separate, or
to indicate the interface between two areas
- Dementia
- Losing your mind.
Chronic intellectual impairment (loss of mental capacity) with organic origins,
that affects a person's ability to function in a social or occupational setting
- Demerol
- A narcotic painkiller.
Trade name for meperidine, a synthetic analgesic often used as a substitute
for morphine
- Demulcent
- Soothing, bland,
allaying the irritation of inflamed or abraded surfaces
- Demyelinating Disease
- Diseases
in which the myelin sheath of nerves is destroyed and that often have an autoimmune
component
- Denaturation
- Reversible or
irreversible loss of function in proteins and nucleic acids resulting from loss
of higher order secondary, tertiary or quaternary structure) produced by nonphysiological
conditions of pH, temperature, salt or organic solvents
- Dendritic
- Branching
- Dendritic Cell
- A type of antigen-presenting
immune cell. Dendritic cells have elongated, tentacle like branches in which
they trap foreign objects
- Depletion
- Removal
- Depressant
- Drug that reduces
exaggerated functional activity of the tissues
- Deprivation
- Loss of, lack
of
- Dermal
- Relating to the skin
- DES
- Diffuse Esophageal Spasm
- Desensitization
- The reduction
or abolition of allergic sensitivity or reactions to the specific antigen (allergen)
- Desert Tea
- Also known as Brigham
Young weed, Desert herb, Mormon tea, Squaw tea, and Teamster's tea. Used as
a diuretic, febrifuge, and tonic. Also used as a remedy for kidney and bladder
problems
- Detoxification
- Neutralization
of or degradation of toxic or other dangerous substances. Removal of poisonous
substances
- Detoxify
- To change a harmful
substance into a safer form
- Devil's Claw
- Harpagophytum
Procumbens. Belongs to the family Pedaliaceae. Has been used for treating a
wide variety of conditions. Possesses analgesic, sedative and diuretic properties.
Devil's claw has been recommended for treating a wide variety of conditions
including diseases of the liver, kidneys, and bladder, as well as allergies,
arteriosclerosis, arthritis, climacteric (change of life) problems, gastrointestinal
disturbances, headache, heartburn, lumbago, menstrual difficulties, neuralgia,
nicotine poisoning, and rheumatism. Reported to help with joint pain while improving
vitality in the joints. It is free from side effects and seemingly lacks any
appreciable toxicity
- Dextrose
- Another term for
glucose, the simple sugar which results from the complete digestion of many
carbohydrates
- DG
- Diacylglycerol
- DH
- Diaphragmatic Hernia
- DHEA
- Dehydroepiandrosterone--Decreases
the stickiness of platelets,
small particles in the blood that often clump together and cause heart attacks
and strokes. Shown to be helpful in Cancer, Alzheimer's disease, Chronic fatigue
syndrome, Multiple Sclerosis, Memory loss, and Parkinson's disease. Increases
the level of estrogen in women and testosterone in men to levels found in younger
men and women
- DHHS
- Dept. of Health and Human
Services
- DI
- Distal Intestine
- Dia
- (prefix)- through; between
- Diabetes
- Disease characterized
by increased urination. Usually refers to diabetes
mellitus
- Diabetes Mellitus
- Condition
characterized by abnormally high blood sugar due to insufficient insulin activity
- Diabetic Keto Acidosis
- An
illness in which increased acidity of the blood is caused by the breakdown products
(ketones) of fat metabolism, because of a shortage of Insulin
- Diabetic Neuropathy
- A combined
type of nerve damage involving sensory and motor components, typically symmetrical
and involving autonomic nerves (serving the blood vessels and internal organs),
seen frequently in older diabetic patients
- Diagnosis
- Determination of
the nature of a disease or condition or the distinguishing of one disease or
condition from another. Assessment may be made through physical examination,
laboratory tests, or the like, and may be assisted by computerized programs
designed to enhance the decision-making process
- Diagnostic Errors
- Incorrect
diagnoses after clinical examination or technical diagnostic procedures
- Diagnostic Imaging
- Use of
x-ray or ultrasound pictures of the body organs to make diagnoses
- Diagnostic Tests, Routine
- Diagnostic
procedures, such as laboratory
tests and x-rays, routinely performed on all individuals or specified
categories of individuals in a specified situation, e.g., patients being admitted
to the hospital. These include routine tests administered to neonates
- Diagnostic Techniques, Digestive System
- Methods
and procedures for the diagnosis of diseases or dysfunction of the digestive
system or its organs or demonstration of their physiological processes
- Dialysis
- Procedure to filter
blood for patients with kidney failure, also used to remove absorbed toxins
from overdosing and poisoning
- Diaphoresis
- Sweating
- Diaphragm
- Muscle that separates
the abdomen from the chest
- Diarrhea
- Abnormal increase
in the frequency of intestinal evacuations characterized by their fluid consistency
- Diastolic
- Part of blood pressure.
The bottom of two blood pressure numbers, which measures blood pressure when
the heart is at rest
- Diathesis
- Susceptibility to
disease
- DIC
- Abbreviation for disseminated
intravascular coagulation (no blood clotting). In many hospitals, ER personnel
also interpret DIC to mean "death is coming" since disseminated intravascular
coagulation usually means death is imminent
- Dictionary
- A device for starting
futile arguments over definitions
- Differential Diagnosis
- Diagnosis
made by ruling out many disorders. The patient usually presents with symptoms
that can be shared by many conditions. For example, chest pain can be caused
by many diseases or conditions, and each one must be ruled out to arrive at
the correct diagnosis
- Diffusion
- To spread out evenly,
as in a liquid
- Dietary Cholesterol
- Cholesterol
that is in the food you eat. It is present only in foods of animal origin, not
in foods of plant origin. Dietary cholesterol, like dietary saturated fat, tends
to raise blood cholesterol, which increases the risk for heart disease
- Dietary Fats, Unsaturated
- Unsaturated
fats or oils used in foods or as a food
- Dietary Fiber
- Indigestible,
nonstarch material, such as pectins, hemicellulose, plant gums, celluloses,
found in the cell walls of plants. Found in a wide variety of plant foods, including
cereals and whole grain breads, vegetables and fresh fruits, and nuts. Because
dietary fiber resists digestion in the gastrointestinal tract, it accounts for
a significant portion of the solid matter in bowel movements
- Differential
- Related to White
Blood Cell Count, the proportions of the different varieties
- Differential Equation
- The
mathematical formulation corresponding to a continuous model; an equation involving
derivatives
- Differentiated, Well
- Referring
to malignancy, possessing histological characteristics of the originating tissues
- usually suggesting less pathological aggression
- Diffuse
- Scattered, widespread,
not limited to one tissue or spot, disperse
- Diffusion
- Spreading
- Digestion
- Process of breaking
down food into simpler chemical compounds that are capable of being absorbed
by the intestine
- Digestive Aids
- Enzymatic
aid in the digestion of proteins, carbohydrates and fats. Helps promote
intestinal health. Most commonly used digestive aids are hydrochloric acid,
pancreatin and enzyme preparations. Without proper digestion, the molecules
that have not been ingested completely can be inappropriately absorbed into
the systemic circulation, causing various diseases and the development of food
allergies
- Digestive Physiology
- Functions
and activities of the digestive system as a whole or of any of its parts
- Digestive Tract
- Organs that
process food and then store and dispose of the waste products of food. The digestive
tract includes the mouth, esophagus, stomach, liver, small and large intestines,
and rectum
- Dilation
- Condition of being
stretched out, or distended beyond normal size. Dilation is an increase in the
diameter of a segment of a hollow organ such as the intestine
- Dill Seed
- Used as a digestive
aid, eases colic, halt diarrhea, prevent flatulence. Preservative
- Diplopia
- Double vision
- Direct Life Cycle
- A life cycle
in which a parasite is transmitted directly from one host to the next without
an intermediate host or vector of another species
- Direct Patient Contact
- Patient
contacts that are initiated by the study clinic for the purpose of patient recruitment
or data collection and that are directed at specified patients without any reliance
on interviewing persons, agencies, institutions, or generalized advertising
campaigns to make contacts
- Disaster Protocol Color Coding
- The following color tags are used to immediately triage patients during a
mass casualty event: Green is walking wounded; yellow is urgent; red is critical;
black is DOA (Dead On Arrival)
- Discrete Variable
- A variable
is capable of assuming only certain values over a defined range
- Disease
- The debilitating effects
on a host of infection by a parasite
- Disinfection
- Destroy or render
harmless pathogenic (disease-causing) microbes in or on an inert substance
- Dissection
- Identification,
isolation and surgical removal
- Disseminate
- Scatter
- Disseminated
- Spread throughout
the body
- Dissociation
- Separation
- Distal
- Further from central.
Farthest away from the midline, trunk heart, or other reference points
- Distal Pulse
- The pulse farthest
from the heart
- Distension
- Enlarging. Visible
increase in the waistline. Bloating or swelling of the abdomen
- Distomatosis
- Infestation with
or disease caused by digenetic trematode worms, such as liver rot
- Distribution
- The pattern by
which parasite numbers are partitioned amongst available hosts
- Diuresis
- More urine than normal
- Diuretic
- Drug used to increase
urine output, thereby cleansing the excretory system
- Divalent
- Having a chemical
valence of two
- Diverticula
- Plural of diverticulum
- Diverticulitis
- Condition in
which diverticula become inflamed. Inflammation of the colon
- Diverticulosis
- Condition in
which small sacs (diverticula) form in the wall of the colon. This condition
is common among older people
- Diverticulum
- Small sac that
forms on the wall of a hollow organ (usually the colon). The plural form is
diverticula. The liver is an anterior diverticulum of the intestine
- dl
- Deciliter, one tenth of
a liter
- DLC
- Dual Lumen Catheter
- DLPA
- (D.L-Phenylalanine) 50-50
mixture of d-phenylalanine and l-phenylalanine. May help alleviate chronic pain
by increasing endorphin activity (the body s natural painkillers). Phenylalinine
is the precursor of tyrosine, and hence of dopamine, norepinephrine, and epinephrine,
all of which require Vitamins B6 and C for their biochemical conversion processes.
Phenylalinine is also an essential acid required by the thyroid for normal function.
Used in several ways: as a pain control, antidepressant, to improve memory,
concentration and mental alertness, treat symptoms of rheumatoid arthritis,
to reduce symptoms of multiple sclerosis and Parkinson's disease, and to treat
the depigmentation of the skin condition known as Vitiligo
- Dormancy
- Latent
- Dormant
- At rest; clinically
silent.
- DM
- Duodenal Mucosa
- DMSO
- Dimethyl Suloxide--Used
to relieve pain, reduce inflammation, diminish swelling, encourage healing,
and restore normal function. Typically used for a variety of disorders, including
arthritis, cancer, mental retardation, stroke, and various sports injuries
- DNA
- Deoxyribonucleic Acid,
The genetic material which determines a cells activities. It carries the
cells genetic code. DNA is used to store the genetic information of all
living creatures, with the exception of the RNA viruses. The carrier of genetic
information in the nucleus of cells. It determines the structure, function and
behavior of the cell. The blueprint
- DNA Amplification
- The use
of enzymes in making millions or billions of copies of a single DNA sequence
(see PCR)
- DNA Annealing
- The reformation
of double stranded DNA from thermally denatured DNA. The rate of reassociation
depends upon the degree of repetition and is slowest for unique sequences (this
is the basis of the Cot value)
- DNA Binding Protein
- Proteins
that interact with DNA, typically to pack or modify the DNA for example histones
or to regulate gene expression, transcription factors. Among those proteins
that recognize specific DNA sequences, there are a number of characteristic
conserved motifs believed to be essential for specificity
- DNA Diagnosis
- The use of DNA
polymorphisms to detect the presence of a disease gene
- DNA Excision
- The removal of
a damaged segment of a DNA molecule by a group of DNA repair enzymes in order
to repair the molecule
- DNA Fingerprint
- The unique
pattern of DNA fragments identified by Southern hybridisation (using a probe
that binds to a polymorphic region of DNA) or by polymerase chain reaction (using
primers flanking the polymorphic region)
- DNA Gene
- Any of a number of
genes found in the bacteria Escherichia coli which makes proteins that are essential
for DNA replication
- DNA Library
- Genomic Library.
A collection of DNA molecules, derived from restriction fragments that have
been cloned in vectors, that includes all or part of the genetic material of
an organism
- DNA Ligase
- Enzyme
involved in DNA replication
- DNA Ligation
- The joining of
two DNA strands by their ends with a phosphodiester bond
- DNA Melting
- Denaturation of
a DNA molecule with heat. The double-stranded molecule breaks up into two single-stranded
molecules as a result of heat
- DNA Methylation
- Process by
which methyl groups are added to certain nucleotides in genomic DNA
- DNA Modification
- Variety of
chemical changes made to a DNA molecule just after it has been replicated. An
example is DNA methylation
- DNA Polymerase
- Any of several
polymerases that promote replication or repair of DNA usually using single-stranded
DNA as a template. Enzymes involved in template directed synthesis of DNA from
deoxyribonucleotide triphosphates. I, II and III are known in E. coli, III appears
to be most important in genome replication and I is important for its ability
to edit out unpaired bases at the end of growing strands. Animal cells have
and polymerases, with apparently responsible for replication of nuclear DNA
and for replication of mitochondrial. All these function with a DNA strand as
template. Retroviruses possess a unique DNA polymerase (reverse transcriptase)
that uses an RNA template
- DNA Polymerase i
- An enzyme
that aids in DNA replication. It has the following 3 functions: 1. polymerizes
in the 5(r) to 3(r) direction on single-stranded template. 2. degrades single
or double-stranded DNA from a free 3(r)-OH end, and 3. degrades double-stranded
DNA from a free 5(r) end
- DNA Polymerase ii
- An enzyme
that aids in DNA replication. It has a number of different functions, including
the repair of ultraviolet radiation damaged DNA
- DNA Polymerase iii
- An enzyme
that aids in DNA replication. It has a number of different functions, such as:
proofreading newly replicated DNA, removing nucleotides from the 3' end of the
strand one by one, and binding nucleotides from the 5' end of the strand
- DNA Polymerisation
- The making
of a DNA molecule from nucleotide monomers by linking them together in a long
chain (a polymer)
- DNA Probe
- A small piece of
nucleic acid that has been labeled with a radioactive isotope, dye, or enzyme
and is used to locate a complementary nucleotide sequence or gene on a DNA molecule
- DNA-Protein Interaction
- Any
complex that forms between a protein molecule and DNA. Examples are nucleosomes
(structures formed for the purpose of DNA storage) and any gene regulatory protein
(a protein which regulates transcription by binding to a regulatory region on
the DNA)
- DNA Repair
- Enzymic correction
of errors in DNA structure and sequence that protects genetic information against
environmental damage and replication errors
- DNA Replication
- The process
whereby a copy of a DNA molecule is made and thus the genetic information it
contains is duplicated. The parental double stranded DNA molecule is replicated
semi conservatively, i.e. each copy contains one of the original strands paired
with a newly synthesised strand that is complementary in terms of AT and GC
base pairing. Though in this sense conceptually simple, mechanistically a complex
process involving a number of enzymes
- DNR
- Abbreviation for do not
resuscitate, which is requested or ordered for terminally ill patients
- DOA
- Dead On Arrival
- Docks
- Also known as Great
Water Dock, Patience Dock, Red Dock, Round-leaved, Sharp-pointed Dock, and Yellow
Dock. Patience Dock is considered good for jaundice, also has a gentle
laxative action. Round-leaved Dock was formerly given for the cure of
boils. Sharp-pointed Dock , the root has been used in drinks and decoctions
for scurvy and as a general blood cleanser, and used for outward application
to cutaneous eruptions, in the form of an ointment, made by beating it up with
lard. Yellow Dock is applicable to all the purposes for which the other
species are used. The root has laxative, alterative and mildly tonic action,
and can be freely used as a tonic and laxative in bilious complaints, rheumatism,
and as an astringent in piles, bleedings of the lungs, etc. Mostly prescribed
for diseases of the blood, from a spring eruption, to scurvy, scrofula and chronic
skin diseases. Also useful in jaundice and as a tonic to the stomach and the
system in general. Red Dock, or Water Dock, has properties very
similar to those of the Yellow Dock. Its powers as a tonic are, perhaps more
marked than the previous species. For internal use, it is given in an infusion,
in wine glassfull doses. Externally it is used as an application for eruptive
and scorbutic diseases, ulcers and sores, used for cleansing ulcers in affections
of the mouth, etc. As a powder, it has cleansing and detergent effect upon the
teeth. Great Water Dock is strongly astringent, and powdered makes a
good dentifrice. The astringent qualities of the root render it good in case
of diarrhea, the seeds (as with the other Docks) having been used for the same
purpose. The green leaves are said to be an excellent application for ulcers
of the eyes
- Dogsbane
- Apocynum Androsaemifolium--Also
known as Bitter Root, Milkweed, or Fly-Trap. One of the digitalis group of cardiac
tonics, Apocynum, is the most powerful in slowing the pulse, and its action
on the vaso-motor system is also very strong. Being rather irritant to mucous
membranes, it may cause nausea and catharsis. It is a powerful hydragogue, helpful
in dropsy's due to heart failure, and in the ascites of hepatic cirrhosis. Also
used as an alterative in rheumatism, syphilis and scrofula. The absorption in
the gastrointestinal tract being very irregular, the dosage and patient must
be carefully watched and guarded
- DOH
- Department Of Health
- Dong Quai
- Angelica Sinensis--One
of the most important female tonic remedies in Chinese medicine, Dong
Quai is used to provide energy and regulate female hormones. Main active
ingredient is ligustilide which has been shown to normalize uterine contractions,
improve peripheral circulation, relax blood vessels and act as a general blood
tonic. Used in the treatment of female disorders such as menstrual cramps, premenstrual
syndrome, and to relieve symptoms associated with menopause. Also said to purify
the blood and act as a mild laxative. Dong quai also contains compounds that
act to stimulate the central nervous system, supporting its use as a mild energizer.
Certain people may experience a form of dermatitis caused by compounds that
promote photosensitivity. (Interferon)
Pregnant women, and women with excessive menstrual flow,
should avoid using this herb altogether
- Dopamine
- A chemical transmitter,
naturally occurring in nerves, and used in a synthetic form to sustain blood
pressure
- Dorsal
- The back of a body
part, with reference to the standard anatomical convention
- Dose/Dosage
- Dose is the amount
or quanity to be given at one time, or the total amount to be given. Dosage
implies a regimen, the regulated administration of individual doses. Usually
expressed as a quanity per unit of time
- Dose Ranging
- The establishment
of the optimal dosage of a new drug by repeated trials of varying dosages
- Double Blind
- A procedure in
a clinical
trial for issuing and administering treatment assignments by code number
in order to keep study patients and all members of the clinic staff, especially
those responsible for patient treatment and data collection, from knowing the
assigned treatments. Any condition in which two different groups of people are
purposely denied access to a piece of information in order to keep that information
from influencing some measurement, observation, or process
- Double-Blind Study/Trial
- Persons
testing a new therapy for safety and effectiveness can be influenced by their
preconceived ideas or desires. Similarly, patients often report improvement
from treatments if they expect the treatment to work, a phenomenon known as
the placebo effect. To prevent these biases from influencing results, controlled
trials often use codes that hide knowledge of which treatment is being given
from both the investigator and the patient until after the study is complete
- Double Helix
- Structure of
DNA described and discovered by Crick and Watson
- DP
- Diminutive Polyp
- DR
- Diffuse Redness
- Dronabinol-Marinol
- A synthetic
form of the active ingredient in marijuana, used to increase hunger and ameliorate
nausea in persons with severe involuntary weight loss
- Drop Out
- A patient enrolled
in a clinical trial who is either unwilling or unable to return to the study
clinic for regular follow-up visits
- Dropsy
- Abnormal accumulation
of fluid in the body; edema
- Drug Allergy
- Sensitivity or
Hypersensitivity to a drug or chemical, with the potential for causing harmful
consequences
- Drug Induced Cholestasis
-
A condition where a drug is interfering with the normal flow of bile from the
liver to the gut via the biliary tract. The end result is jaundice
- Drug Induced Hepatitis
- Inflammation
of the liver that is caused by a drug. Some medications may cause inflammation
of the liver as a drug side effect or drug toxicity. Drugs that are known to
cause hepatitis include acetaminophen, erythromycin, halothane, isoniazid, methyldopa,
and oral contraceptives
- Drug Side Effect
- An often
undesirable effect that occurs in association with the use of a particular medication.
Examples of common drug side effects include: dizziness, headache, nausea, sedation,
vomiting, and weakness. Drug side effects that occur in 1%, or more, of patients
taking a particular medication are considered to be causally related to the
use of that medication
- Drug Toxicity
- The systemic
effects of a drug that are related to the overall level of the medication in
the bloodstream. Drug toxicity may occur with overdosage of a medication, accumulation
of the drug in the body over time, or the inability of the patient's body to
eliminate the drug
- Drug Trial
- A clinical trial
in which the test treatments are drugs
- DSHEA
- Dietary Supplement
Health and Education Act, A bill passed by Congress in 1994. It recognizes
the valuable role nutritional supplements play in promoting health and opens
the way for consumers to obtain the information they need to make health dietary
choices
- DTH
- Delayed Type Hypersensitivity
- DTP
- Diphtheria-Tetanus-Pertussis
(toxoids/vaccine)
- DTR
- Registered Dietetic Technician
- DU
- Duodenal Ulcer
- Dubin-Johnson Syndrome
- An
inherited form of chronic jaundice (a yellow tint to the eyes and skin) there
is no known cause
- Ductile
- Can be reshaped or
drawn without breaking
- Ductule
- Small duct
- Ductus
- Duct
- Ductus Venous
- A vein passing
through the liver and connecting the left umbilical vein with the inferior vena
cava of the fetus, losing its circulatory function after birth, and persisting
as the ligamentum venosum of the liver
- Ductus Choledochus
- Common
bile duct
- Duffy Blood-Group System
- Blood
group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic
genes, the frequency of which varies profoundly in different races; amorphic
genes are common
- Duo
- Combining form meaning
two
- Duodenitis
- An irritation of
the first part of the small intestine/duodenum
- Duodenum
- Gut, first part of
the small intestine. The first, shortest, and widest part of the small intestine
that in humans is about 10 inches (25 centimeters) long and that extends from
the pylorus to the undersurface of the liver where it descends for a variable
distance and receives the bile and pancreatic ducts and then bends to the left
and finally upward to join the jejunum near the second lumbar vertebra
- D&V
- Diarrhea & Vomiting
- D/W
- Dextrose in water
- Dys
- (prefix)-Difficult; bad;
abnormal
- Dyscrasia
- Bad temper
- Dysentery
- Inflammation of
the colon, marked by intense diarrhea with the passage of small amounts of mucus
and blood, usually caused by pathogenic bacteria or protozoans
- Dysfunction
- Malfunction
- Dyspepsia
- Condition of disturbed
digestion characterized by nausea, heartburn, pain, and gas. Another name for
indigestion
- Dysphagia
- Difficulty swallowing,
usually caused by blockage or injury to the esophagus
- Dysphasia
- Impairment of speech
- Dysplasia
- The abnormal development
of tissue. In disease, the alteration of size, shape, and organization of adult
cells. May be precursor of cancer
- Dyspnea
- Difficult or labored
breathing. Shortness of breath
- Dysregulation
- Refers to interruption
or interference of normal process(es)
- Dystonia
- Spasmotic movements
due to disordered tonicity of muscle
© Vikki Shaw |
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