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Safety and Immunogenicity of
Hepatitis A Vaccine in Patients With Chronic Liver Disease

table  1.   Subject Characteristics at Enrollment
Healthy (n = 188) Chronic Hepatitis C Vaccinated With Hepatitis A Vaccine (n = 104) Chronic Hepatitis C Vaccinated With Hepatitis B Vaccine (n = 67) Chronic Hepatitis B (n = 46) Other CLD (n = 70)
Mean age (range) (yr) 39.8 (19-73) 40.9 (23-69)dagger 45.0 (25-67) 38.3 (18-67) 43.1 (20-70)
Gender ratio (M/F)* 47.8/52.2 63.8/35.2 68.7/31.3 71.7/28.3 53.6/46.4
Serological status    seronegative for markers for hepatitis A, B and C    anti-HCV positive    anti-HCV positive    HBsAg positive in two blood samples 6 months apart    seronegative for markers for hepatitis A, B and C
   seronegative for markers for hepatitis A    seronegative for markers for hepatitis B    seronegative for markers for hepatitis A
NOTE. ANOVA of mean ages was not significant for sex (P = .91) and interaction sex-group (P = .67), but was significant for group (P = .0015). Ratio of males to females was significantly different (Fisher's Exact test, P = .002).
Abbreviations: hepatitis A viral marker, anti-HAV; hepatitis C viral marker, anti-HCV; hepatitis B viral marker, HBsAg, anti-HBs, anti-HBc, anti-HDV, anti-HBe.
* Gender ratio expressed in percentage (%).
dagger Age and sex not recorded for one subject.

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