|
|
Safety and Immunogenicity of
Hepatitis A Vaccine in Patients With Chronic Liver Disease
|
table 3. Seroconversion
Rates and GMT
|
|
|
Timing |
(n) |
Seroconversion
|
GMC |
95% Confidence Interval |
| (n) |
% |
|
| Group1: healthy adults |
month 1 |
185 |
172 |
93.0 |
175 |
150-206 |
| |
month 2 |
186 |
162 |
87.1 |
100 |
87-115 |
|
month 6 |
180 |
132 |
73.3 |
74 |
63-87 |
|
month 7 |
167 |
164 |
98.2 |
1315 |
1086-1593 |
| Group 2: chronic hepatitis B |
month 1 |
43 |
36 |
83.7 |
93 |
68-127 |
| |
month 2 |
46 |
33 |
71.7 |
69 |
49-97 |
|
month 6 |
45 |
23 |
51.1 |
43 |
31-60 |
|
month 7 |
44 |
43 |
97.7 |
749 |
519-1080 |
| Group 3: chronic hepatitis C |
month 1 |
99 |
73 |
73.7* |
77 |
60-98 |
| |
month 2 |
97 |
55 |
56.7* |
47 |
38-58 |
|
month 6 |
93 |
35 |
37.6* |
32 |
26-40 |
|
month 7 |
87 |
82 |
94.3 |
467 |
345-631 |
| Group 5: others |
month 1 |
65 |
54 |
83.1* |
112 |
83-149 |
| |
month 2 |
66 |
48 |
72.7* |
64 |
50-81 |
|
month 6 |
63 |
40 |
63.5 |
44 |
36-53 |
|
month 7 |
63 |
60 |
95.2 |
562 |
403-783 |
|
|
NOTE. Month 1, etc.: blood sample obtained one month after
dose 1, etc. Seroconversion rates in each group of CLD patients
were compared with that in healthy subjects by Fisher's Exact test.
For calculation of GMCs, negative values were given an arbitrary
value of one half the cut-off. 95% confidence interval = lower
and upper 95% confidence interval.
Abbreviations: GMC, geometric mean anti-HAV concentration; others,
CLD of etiology other than hepatitis B or C; seroconversion, seropositive
for anti-HAV with titer 33 mIU/mL.
* P < .01.
|
|
Return To Article
|
|