Hepatitis Central

The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatments.

Safety and Immunogenicity of
Hepatitis A Vaccine in Patients With Chronic Liver Disease

table  3.   Seroconversion Rates and GMT
Timing (n) Seroconversion
GMC 95% Confidence Interval
(n) %
Group1: healthy adults month 1  185 172 93.0 175 150-206
   month 2  186 162 87.1 100 87-115
month 6  180 132 73.3 74 63-87
month 7  167 164 98.2 1315 1086-1593
Group 2: chronic hepatitis B month 1  43 36 83.7 93 68-127
   month 2  46 33 71.7 69 49-97
month 6  45 23 51.1 43 31-60
month 7  44 43 97.7 749 519-1080
Group 3: chronic hepatitis C month 1  99 73 73.7* 77 60-98
   month 2  97 55 56.7* 47 38-58
month 6  93 35 37.6* 32 26-40
month 7  87 82 94.3 467 345-631
Group 5: others month 1  65 54 83.1* 112 83-149
   month 2  66 48 72.7* 64 50-81
month 6  63 40 63.5 44 36-53
month 7  63 60 95.2 562 403-783

NOTE. Month 1, etc.: blood sample obtained one month after dose 1, etc. Seroconversion rates in each group of CLD patients were compared with that in healthy subjects by Fisher's Exact test. For calculation of GMCs, negative values were given an arbitrary value of one half the cut-off. 95% confidence interval = lower and upper 95% confidence interval.
Abbreviations: GMC, geometric mean anti-HAV concentration; others, CLD of etiology other than hepatitis B or C; seroconversion, seropositive for anti-HAV with titer 33 mIU/mL.
* P < .01.

Return To Article

Site Topics

  • Frequently Asked Questions

    Some of our most commonly asked questions and our answers to them.

  • HCV Symptoms

    You'll find links to a comprehensive symptoms list, as well as various studies and discussions about Hepatitis C symptoms.

  • Lab Tests

    What they are and what they mean. Helps you interpret & understand all the various hepatitis lab tests likely to be encountered.

  • Hepatitis C Genotypes

    Learn about Hepatitis C Genotypes and their variants.

  • Viral Load

    Provides detailed information on how to analyze and interpret viral load numbers as well as a link to a convenient Viral Load Chart.

  • What is...?

    Learn more about various Hepatitis C related topics, including HCV, Ascites, Biopsies, and much more.

  • HCV Medicines

    Numerous links to studies, info sheets, FAQs, and analysis of Ribavirin/Rebetron medicines.

  • Glossary

    Commonly used medical terms and definitions.

  • Hepatitis C Doctors

    A state-by-state and worldwide reference listing physicians who treat HCV, including an email link to submit your physician for inclusion.

  • Biopsy Info

    A comprehensive resource of information relating to the liver biopsy.

  • Cirrhosis

    Many discussions and analyses of cirrhosis, including causes, complications, pathology, symptoms, and much more.

  • Liver Cancer

    Liver Cancer/Hepatocellular Carcinoma studies, info sheets, FAQs, and analysis.

  • Liver Disease Medicines

    An exhaustive list of links to studies, info sheets, FAQs, and analysis of the various drugs used to treat liver disease.

  • Hep-Central Email List

    Sign up to learn about advances and breakthroughs in Hepatitis C research, including information about medical and complementary treatments.

  • HCV Links

    Convenient links to other sites external to Hepatitis-Central.

  • HCV Transmission

    Information about the transmission of Hepatitis C.

  • HCV Natural Remedies

    A number of herbal products useful in the management of liver disease.

  • HCV Books

    Recommended reading for those interested in hepatitis information.

  • Hepatitis C Forum

    A Bulletin Board for discussions on hepatitis, treatments, etc.

  • Hepatitis C Activism

    An easy way to get involved in urging our government to do more for Hepatitis C awareness and treatment research.

Advertisement(s)

Advertisement