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Early Hepatocellular Carcinoma as an Entity With a High Rate of Surgical Cure

table 2.Pathological Characteristics of HCC in 67 Patients
Characteristic No. of Patients (%)
P
Early HCC Group (n = 15) Overt HCC Group (n = 52)
Gross typing
  Type-1 0  23 (44)
  Type-2 0  8 (15)
  Type-3 0  21 (41)
  Type-early 15 (100) 0 
Glisson's triad present* 15 (100) 3 (6)dagger <.001
Edmondson's grading <.001
  Grade-1 15 (100) 0 
  Grade-2 0  42 (81)
  Grade-3 0  10 (19)
Capsular formation 0  36 (69) <.001
Regional cancer spread 1 (7) 22 (42)Dagger .01
  Vascular invasion 1 (7) 15 (29)
  Intrahepatic metastasis§ 0  11 (21)
Underlying liver disease .72
  Chronic hepatitis 2 (13) 11 (21)
  Cirrhosis 13 (87) 41 (79)
Dysplastic nodules or foci 7 (47) 18 (35) .55
* Presence of Glisson's triad within the tumor was assessed macroscopically and later confirmed microscopically.
dagger The tumors in these patients contained discrete foci of overt HCC (type-1 and grade-2) in a grade-1 background with Glisson's triad, and appeared as "nodule-in-nodule" lesions.
Dagger Of them, tumors in four patients had both invasion and metastasis.
§ Tumors were considered metastatic if they presented as smaller lesions around a main tumor and exhibited similar histological characteristics, or if they grew from portal vein tumor thrombi.1

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