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Early Hepatocellular Carcinoma as an Entity With a High Rate of Surgical Cure

table 3. Postsurgical Recurrence of HCC in 59 Patients
Profile No. of Patients (%)
P
Early HCC Group With Recurrence (n = 12) Overt HCC Group With Recurrence (n = 47)
Timing of recurrence <.001
  Early (<3 yr) 1 (8) 35 (74)
  Late (3 yr) 11 (92) 12 (26)
Number of tumors .27
  Single 8 (67) 20 (43)
  Two or three 3 (25) 15 (32)
  Four or more 1 (8) 12 (25)
Mode of spread .50
  Local 0 4 (9)
  Unilobar 8 (67) 25 (53)
  Bilobar 4 (33) 18 (38)
Treatment for recurrence* .55
  Second surgerydagger 2 (17) 5 (11)
  Ethanol injection 3 (25) 8 (17)
  Arterial embolization 6 (50) 33 (70)
  NoneDagger 1 (8) 1 (2)
Median (range) duration (yr)
  Time to recurrence 3.9 (2.1-11.9) 1.7 (0.2-7.9) <.001
  Survival after recurrence 2.3 (0.2-5.2) 2.4 (0.3-8.1) .51
* Selection of treatment depended on the pattern of recurrence and patient's will.
dagger In seven patients who underwent a second surgery, a total of 12 tumors (18 ± 5 mm) resected were HCC of type-1 to -3 (n = 10) or type-early (n = 2).
Dagger One patient in each group refused treatment.

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