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Full-Length Complementary DNA of Hepatitis C Virus Genome From an Infectious Blood Sample

table  1.   Sequences of HVR and Number of Clones Recovered
Clonedagger Sequence of HVR No. of Clones*
DonorDagger ChimpDagger 3 Wk Recipient
4 Wk 5 Wk 14 Wk 16 Wk
384410§
A1 HYRVTRGVQGHVTSTLTSLFRPGASQK 18 1 2 1 0 0
A2 S-------------------------- 3 0 0 0 0 0
B1 N-H---A----GAFG-----Q------ 5 19 0 0 2 0
B2 D-H---A----GAFG-----Q------ 0 0 0 1 1 0
B3 D-H---A----GAF------TL----- 1 0 0 0 0 0
B4 N-H---A----GAF------TS----- 0 0 1 0 0 0
B5 D-H---A----GAF------TS----- 2 0 0 0 1 0
B6 D-H---A----GAFQ-----TS----- 0 0 1 0 0 0
B7 D-H---A----GAFQ-----TS----R 0 0 1 0 0 0
B8 D-H---A----GAFH-----TS----- 0 0 2 8 6 0
B9 D-H---A--C-GAFH-----TS----- 0 0 1 0 0 0
C1 --H---A---RSV-K--AF-T--P--- 1 0 0 0 0 0
C2 N-H-------R-A-K---F-T--P--- 0 0 1 0 0 0
D1 --H---------------FK-S----- 0 0 1 0 0 0
E1 E-H----SA--TV-GFV--LA---K-N 0 0 0 0 0 10
Total 30 20 10 10 10 10
* Numbers of clones recovered from plasma of donor, chimpanzee, and recipient are shown here; wk, weeks posttransfusion.
dagger Clone names shown in Fig. 4.
 Dagger Number according to Hijikata et al.38
§ Numbers written above amino acid residues indicate positions in polyprotein of HCV. Dashes represent amino acid residues identical to the A1 clone.

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