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Hepatitis C Virus RNA Profiles in Chronically Infected Individuals: Do They Relate to Disease Activity?

table  1.   Histological Features Observed in Chronic HCV Patients in Relation to Transaminase Profile and Viremia Levels
Minimal
Changes 		Mild
CH 		Moderate
CH 		Severe
CH 		P
ALT pattern over 12 months
  Normal ALT 3 15  5 0 .012
  Fluctuating 0 10 15 1
HCV-RNA fluctuations
  delta < 0.5 Log 3/3  3/15 3/12 0 NS
  delta greater than 0.5 Log 0 12/15 9/12 1/1
NOTE.   delta represents the difference between the maximum and minimum value of HCV RNA measured over time in each individual patient. 0.5 Log is considered the cut-off for the intrinsic variability of the assay.
Abbreviations: CH, chronic hepatitis; NS, not significant.

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