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Hepatitis C Virus RNA Profiles in Chronically Infected Individuals: Do They Relate to Disease Activity?

table  3.   Maximum Changes of HCV RNA (Log genomes/mL) Observed in Serum During Follow-up in HCV-Infected Patients
Monthly Sampling
Yearly Sampling
No. of
Cases 		HCV-RNA Change
(mean ± SD) 		HCV-RNA Change
(range) 		No. of
Cases 		HCV-RNA Change
(mean ± SD) 		HCV-RNA Change
(range)
ALT profile
  Normal ALT 28 0.7 ± 0.3* 0.2-1.4 10 0.8 ± 0.7 0.2-2.2
  Elevated ALT 26 1.3 ± 0.7dagger gif 0.3-3.1 12 1.0 ± 0.5 0.5-1.7
Genotype
  Genotype 1  38 1.0 ± 0.5 0.2-2.2 7 1.0 ± 0.6 0.4-1.9
  Genotype 2  14 1.1 ± 0.8 0.3-3.0 15 0.7 ± 0.5 0.2-1.8
  Genotype 3  2 2.4 ± 1.1 1.6-3.1 0
Liver histology
  Minimal changes 2 0.3 ± 0.24 0.2-0.4 1 0.2 0.2
  Mild CH 18 1.3 ± 0.8 0.3-2.2 7 1.3 ± 0.7 0.4-2.2
  Moderate CH 16 1.2 + 0.9 0.3-3.1 4 1.2 + 0.5 0.7-1.8
  Severe CH 1 1.6 1.6 0  -   -
Abbreviation: CH = chronic hepatitis.
* vs dagger gifP = .004.

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