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Hep C and Fatty Liver Disease Linked by Enzyme
Pittsburgh researchers have found that an enzyme known to participate in fat production is elevated in those with Hepatitis C. Further exploration of this enzyme could help physicians better predict which HCV patients are at risk of developing fatty liver...
ANA773 Resumes Race Against Hepatitis C
By reducing the dosing schedule in half, Anadys Pharmaceuticals returns to their investigation of ANA773, a Toll-Like Receptor-7 agonist prodrug. Approaching the Hepatitis C virus differently from most other contenders, Phase I clinical trials evaluating the safety, tolerability and viral-load...
Popular Illegal Drug Extra Harmful with HCV
Although scores of Americans are turning to the street drug methamphetamine to keep them awake and thin, scientists have found that it worsens Hepatitis C infection in two worrisome ways....
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Herbal Products for Liver Diseases:
A Therapeutic Challenge for the New Millennium
| table 1.
Selection of Herbal Preparations With Proven Hepatotoxicity |
|
| Causative Plants |
Toxic Agents |
Symptoms |
Mechanism/Pathology |
|
Crotalaria
Senecio
Heliotropium
Symphytum officinale (Comfrey) |
Pyrrolizidine alkaloids |
Veno-occlusive disease |
Endothelial cell glutathione
depletion, central vein necrosis, thrombosis, and fibrosis |
| Atractylis gummifera |
Atractylate, gummiferin |
Hepatitis |
Inhibition of oxidative
phosphorylation, hepatic necrosis |
| Callilepsis laureola |
Atractylate |
Hepatitis |
Hepatocyte necrosis |
| Chelidonum majus (greater
celandine) |
Chelidonine, sanguinarine, berberine,
coptisine? |
Hepatitis (cholestatic) |
Lymphocyte infiltration |
| Larrea tridentata
(chaparral) |
Guaiaretic acid derivatives |
Hepatitis |
? |
| Teucrium chamaedrys
(germander) |
Furano-diterpenoids |
Hepatitis |
Hepatocyte glutathione depletion and
apoptosis |
| Chinese herbal mixtures (artemisia,
hare's ear, chrysanthemum, plantago seed, gardinia, red peony root,
etc.) |
Largely undefined |
Hepatitis |
? |
|
| NOTE. Data are selected from Larrey
and Pageaux,5 Kaplowitz,6 Benninger et
al.,9 and Yoshida et al.4 |
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