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Nippon Rinsho 1997 Mar;55(3):559-563
GB virus C/Hepatitis G virus infection in patients
with chronic non-B, non-C hepatitis.
Tanaka E
Second Department of Internal Medicine, Shinshu University School
of Medicine.
We tested HGV RNA in serum in addition to HBV DNA and HCV RNA to
study the causative agents involved in chronic non-B, non-C hepatitis.
Twenty five patients diagnosed as having chronic non-B, non-C hepatitis(negative
for HBsAg and HCV-Ab), were investigated in this study. HGV RNA
was detected by nested RT-PCR using primers in 5'-untranslated,
NS3 and NS5 regions. Of the 25 patients, 4(16%) were positive for
HGV RNA, only 1(4%) was positive for HBV DNA and none were positive
for HCV RNA. Of the 4 patients with HGV RNA, 2 histologically has
mild fibrosis and the remaining 2 had cirrhosis. One patient with
cirrhosis also had hepatocellular carcinoma; HBV DNA was positive
in this patient. All 3 patients with only the HGV infection had
a mild histological grade. In conclusion, HGV infection was involved
in 16% of Japanese patients with chronic non-B, non-C hepatitis.
Chronic Hepatitis G seemed to exhibit mild hepatitis activity.
PMID: 9086758, MUID: 97241510
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