Hepatitis C, table 4, Prospective Study of InterferonTherapy for Compensated Cirrhotic Patients With Chronic Hepatitis Cby Monitoring Serum Hepatitis C RNA

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Prospective Study of Interferon Therapy for Compensated Cirrhotic Patients With Chronic Hepatitis C by Monitoring Serum Hepatitis C RNA

table  4.   Adverse Events and Tolerability in the Study
Randomized
Nonrandomized Total
+16 Weeks +32 Weeks
Number of patients 37 36 84 157
Dose reduction 8 16 30 54
from 9 to 6 MU 6 12 20 38
from 9 to 3 MU 2 4 10 16
Discontinuation 2 8 55 65
(Adverse events)
Depression, loss of appetite 3 15 18
Thrombocytopenia 1 6 7
Skin eruption 2 3 5
Dyspnea 3 3
Severe abnormal liver function 2 2
Alopecia 2 2
Fever 1 1
Palpitation 1 1
Hypothyroidism 1 1
Diabetes mellitus 1 1
Cerebral hemorrhage 1 1
Subarachnoid hemorrhage 1 1
Severe earache 1 1
Uveitis 1 1
Severe vertigo 1 1
Facial nerve palsy 1 1
(Other reasons)
Detection of malignancy 5 5
Progression of liver disease 5 5
Patient's request 1 7 8

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