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Arch Intern Med 1986 Apr;146(4):677-680
Diagnostic value of antithrombin III and aminopyrine
breath test in liver disease.
Rodzynek JJ, Preux C, Leautaud P, Abramovici J, Di Paolo A, Delcourt
AA
To assess the value of the aminopyrine breath test (ABT) and antithrombin
III (AT III) determinations in liver disease, both tests were performed
on 77 consecutive patients who underwent liver biopsies for increased
values of liver enzymes and in 20 patients with clinical cirrhosis. The
mean values of AT III and ABT were significantly lower in cases of liver
cirrhosis than in cases of steatosis and steatofibrosis. The AT III and
ABT values were abnormal in, respectively, 83.9% (26/31) and 90.3% (28/31)
of the patients with cirrhosis and 22.7% (15/66) and 28.8% (19/66) of
the patients without cirrhosis. The association of the two tests increased
the specificity without modifying the sensitivity. Both the AT III test
and the ABT can be used as noninvasive diagnostic procedures for cirrhosis
in patients for whom the liver biopsy is not available or contraindicated.
PMID: 3963948, UI: 86185804
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