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Immune specialist gets loan for hepatitis C trials
Cytheris SA, a specialist in immunotherapy, has been awarded a ?1.5 million interest free loan by OSEO, France?s national agency for industrial innovation, to support its ongoing clinical development programme in hepatitis C (HCV). The OSEO award

Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
SAN FRANCISCO 'These clinical results with JX-594 in end-stage liver cancer patients represent a major step forward for JX-594 against this difficult to treat cancer. We are excited by the potential to fulfill the huge unmet medical needs for these

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Natalie Cole Optimistic About Her Battle with Hepatitis C
Although currently recovering from combination therapy's side effects, the well-respected vocalist Natalie Cole may have conquered the Hepatitis C virus....

Hep C and Fatty Liver Disease Linked
Pittsburgh researchers have found an enzyme known to participate in fat production is elevated in those with Hepatitis C. Further exploration of this enzyme could help physicians better predict which HCV patients are at risk of developing fatty liver disease....

Anadys' ANA773 Hepatitis C Phase I Trials in Netherlands
Reducing the dosing schedule in half, Anadys Pharmaceuticals continues its investigation of ANA773, a Toll-Like Receptor-7 agonist prodrug. Approaching the Hepatitis C virus differently from most other contenders, Phase I clinical trials evaluating the safety, tolerability and viral-load decline associated...

Determinants of Outcome of Compensated Hepatitis C Virus-Related Cirrhosis

References

1. Feray C, Gigou M, Samuel D, Paradis V, David MF, Lemonnier C, et al. The course of hepatitis C virus infection after liver transplantation. HEPATOLOGY 1994; 20: 1137-1143[Abstract].

2. Seef LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter HJ, Iber FL, et al. Long-term mortality after transfusion-associated Non-A, Non-B hepatitis. N Engl J Med 1992; 327: 1906-1911[Medline].

3. Koretz RL, Abey H, Coleman E, Gitnick G. Non-A, non-B post-transfusion hepatitis: looking back in the second decade. Ann Intern Med 1993; 119: 110-115[Medline].

4. Di Bisceglie AM, Goodman ZD, Ishak KG, Hoofnagle JH, Melpolder JJ, Alter HJ. Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. HEPATOLOGY 1991; 14: 969-74[Abstract].

5. Hopf U, Küther D, Stemerowicz R, Stemerowicz R, Lobeck H, Lüdtke-Handjery A, et al. Long-term follow-up of posttransfusion and sporadic chronic hepatitis non-A, non-B and frequency of circulating antibodies to hepatitis C virus (HCV). J Hepatol 1990; 10: 69-76[Medline].

6. Tremolada F, Casarin C, Alberti A, Drago C, Tagger A, Ribero ML, et al. Long-term follow-up of non-A, non-B (type C) post-transfusion hepatitis. J Hepatol 1992; 16: 273-281[Medline].

7. Tong JM, El-Farra NS, Reikes AR, Co RL. Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 1995; 332: 1463-1466[Medline].

8. Colombo M, De Franchis R, Del Ninno E, Sangiovanni A, De Fazio C, Tomasini M, et al. Hepatocellular carcinoma in italian patients with cirrhosis. N Engl J Med 1991; 325: 675-680[Medline].

9. Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, et al. A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. HEPATOLOGY 1993; 18: 47-53[Abstract].

10. Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993; 328: 1797-1801[Medline].

11. Cottone M, Turri M, Caltagirone M, Parisi P, Orlando A, Fiorentino G, et al. Screening for hepatocellular carcinoma in patients with Child's A cirrhosis: an 8-years prospective study by ultrasound and alphafetoprotein. J Hepatol 1994; 21: 1029-1034[Medline].

12. Nousbaum JB, Pol S, Nalpas B, Landais P, Berthelot P, Bréchot C, the Collaborative Study Group. Hepatitis C virus type 1b (II) infection in France and Italy. Ann Intern Med 1995; 122: 161-168[Medline].

13. Mita E, Hayashi N, Kanazawa Y, Hagiwara H, Ueda K, Kasahara A, et al. Hepatitis C virus genotype and RNA titer in the progression of type C chronic liver disease. J Hepatol 1994; 21: 468-473[Medline].

14. Pozzato G, Kaneko S, Morreti M, Saveria Croce L, Franzin F, Unoura M, et al. Different genotypes of hepatitis C virus are associated with different severity of liver disease. J Med Virol 1994; 43: 291-296[Medline].

15. Yamada M, Kakumu S, Yoshioka K, Higashi Y, Tanaka K, Ishikawa T, et al. Hepatitis C virus genotypes are not responsible for development of serious liver disease. Dig Dis Sci 1994; 39: 234-239[Medline].

16. Nishiguchi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S, et al. Randomised trial of effects of interferon-alfa on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet 1995; 346: 1051-1055[Medline].

17. Mazzela G, Accogli E, Sottili S, Festi D, Orsini M, Salzetta A, et al. Alpha interferon treatment may prevent hepatocellular carcinoma in HCV-related liver cirrhosis. J Hepatol 1996; 24: 141-147[Medline].

18. Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van Heuverswyn H, et al. Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J Gen Virol 1993; 74: 1093-1102[Medline].

19. Simmonds P, Alberti A, Alter HJ, Bonino F, Bradley DW, Brechot C, et al. A proposed system for the nomenclature of hepatitis C viral genotypes. HEPATOLOGY 1994; 19: 1321-1324[Medline].

20. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. HEPATOLOGY 1981; 1: 431-435[Abstract].

21. Kaplan EL, Meier P. Non parametric estimation for incomplete observation. J Am Stat Assoc 1958; 53: 457-481.

22. Cox DR. Regression models and lifes tables. J R Stat Soc B 1972; 34: 248-275.

23. Serfaty L, Chazouillères O, Poujol-Robert A, Morand-Joubert L, Dubois C, Chrétien Y, et al. Risk factors for liver cirrhosis in patients with chronic HCV infection: results of a case control study. HEPATOLOGY 1997; 26: 776-779[Abstract].

24. Pagliaro L, Craxi A, Camma C, Tine F, Di Marco V, Lo Iacono O, et al. Interferon-alpha for chronic hepatitis C: an analysis of pretreatment clinical predictors of response. HEPATOLOGY 1994; 19: 820-828[Abstract].

25. Camps J, Crisostomo S, Garcia-Granero M, Riezu-Boj JI, Civeira MP, Prieto J. Prediction of the response of chronic hepatitis C to interferon alfa: a statistical analysis of pretreatment variables. Gut 1993; 34: 1714-1717[Abstract].

26. Serfaty L, Giral P, Loria A, Andréani T, Legendre C, Poupon R. Factors predictive of the response to interferon in patients with chronic hepatitis C. J Hepatol 1994; 21: 12-17[Medline].

27. Fattovich G, Giustina G, Degos F, Tremolada F, Diaodati G, Almasio P, et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 1997; 112: 463-472[Abstract].

28. Castilla A, Prieto J, Fausto N. Transforming growth factors b 1 and alfa in chronic liver disease. Effects of interferon therapy. N Engl J Med 1991; 324: 933-940[Medline].

29. Manabe M, Chevallier M, Chossegros P, Causse X, Guerret S, Trepo C, et al. Interferon-alfa 2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: a quantitative histological evolution. HEPATOLOGY 1993; 18: 1344-1349[Abstract].

30. Camps J, Castilla A, Ruiz J, Civeira MP, Prieto J. Randomised trial of lymphoblastoïd alfa-interferon in chronic hepatitis C. Effect on inflammation, fibrogenesis and viremia. J Hepatol 1993; 17: 390-396[Medline].

31. Jimenez SA, Freundlich B, Rosenbloom J. Selective inhibition of human diploïd fibroblast collagen synthesis by interferon. J Clin Invest 1984; 74: 1112-1116[Medline].

32. Mavier P, Préaux AM, Charlotte F, Dhumeaux D, Rosenbaum J. Effects of alpha- and gamma-interferons on the growth and collagen synthesis of human hepatic myofibroblastic Ito cells [Abstract]. HEPATOLOGY 1992; 16: 185A.

33. Saibara T, Maeda T, Miyazaki M, Onishi S, Yamamoto Y. Depressed immune function in patients with cirrhosis before emergence of hepatocellular carcinoma. HEPATOLOGY 1993; 18: 315-319[Abstract].

34. Baron S, Tyring SK, Fleischmann WR, Coppenhauer DH, Niesel DW, Klimpel GR. The interferons. Mechanisms of action and clinical applications. JAMA 1991; 266: 1375-1383[Medline].

35. Sing RK, Gutman M, Bucana CD, Sanchez R, Llansa N, Fidler IJ. Interferon alfa and down-regulate the expression of basic fibroblast growth factor in human carcinoma. Proc Natl Acad Sci U S A 1995; 92: 4562-4566[Medline].

36. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life- threatening hemangiomas of infancy. N Engl J Med 1992; 326: 1456[Medline].

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