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Extended Drug Therapy for Hepatitis Is Challenged
Patients who do not initially respond to standard drug therapy for treatment of hepatitis C are unlikely to respond to long-term maintenance therapy as well, according to a new study. Yet many patients who do not at first respond to drugs are placed on

Gilead Sciences, Inc. (GILD) Release: Data Demonstrating Significant Efficacy of Viread(R) in Treating Chronic Hepatitis B Published in New England Journal of Medicine
FOSTER CITY, Calif.--(BUSINESS WIRE)-- (Nasdaq: GILD) today announced the publication of detailed 48-week data from two Phase III pivotal clinical trials evaluating the safety and efficacy of its once-daily Viread (tenofovir disoproxil fumarate) for the

Interferon as long-term treatment for hepatitis C not effective
Results of the 3-year study, called the HALT-C (Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis) Trial, appear in today's issue of . The researchers found no difference in the rate of progression of liver disease among patients who received

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Hep C Study Reveals Taribavirin a Good Alternative to Ribavirin
At the end of a 48-week, Phase IIb study, taribavirin shows similar effectiveness as ribavirin in reducing Hepatitis C viral load. However, participants taking taribavirin had a significantly lower rate of anemia....

Schering-Plough Developing Potent Protease Inhibitor for Hepatitis C
An ongoing Phase IIa study on Schering-Plough's next generation Hepatitis C protease inhibitor is encouraging. According to the company, SCH 900518 is 10 times more potent than other medications in this class and is active against highly resistant Hepatitis C...

New Drug Finds Viral Hiding Spots
A new, experimental drug helps the immune system locate a virus by flagging cells that have turned inside out. Hepatitis C is among the viruses that could benefit from Bavituximab's unique strategy of exposing a virus in hiding....

Hepatitis C: Somber Views of Natural History and Optimistic Views of Interferon Treatment?

References

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2. Taylor-Robinson SD, Foster GR, Arora S, Hargreaves S, Thomas HC. Increase in primary liver cancer in the UK, 1979-1994. Lancet 1997; 350: 1142-1143.

3. Deuffic S, Poynard T, Buffat L, Valleron AJ. Trends in primary liver cancer [Letter]. Lancet 1998; 351: 214-215.

4. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825-832[ [ Link previously at www.ncbi.nlm.nih.gov ]].

5. Deuffic S, Buffat L, Poynard T, Valleron AJ. La modelisation de l'histoire naturelle de l'epidemie d'hepatite C permet de predire une augmentation considerable de la mortalite par cancer primitif du foie. Strasbourg. Assosiation Francaise pour Etude du Foie 1997.

6. Nishigushi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S, Shiomi S, et al. Randomised trial of effects of interferon-alfa on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet 1995; 346: 1051-1055[ [ Link previously at www.ncbi.nlm.nih.gov ]].

7. Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S, Iijima A, et al. Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. HEPATOLOGY 1998; 27: 1394-1402[.

8. Serfaty L, Aumaître H, Chazouillèrres O, Bonnan A-M, Rosmorduc O, Poupon E, Poupon R, et al. Determinants of outcome of compensated HCV-related cirrhosis. HEPATOLOGY 1998; 27: 1435-1440[Abstract].

9. Camma C, Giunta M, Linea C, Pagliaro L. The effect of interferon on the liver in chronic hepatitis C: a quantitative evaluation of histology by meta-analysis. J Hepatol 1997; 26: 1187-1199[ [ Link previously at www.ncbi.nlm.nih.gov ]].

10. Poynard T, Leroy V, Cohard M, Thevenot T, Mathurin P, Opolon P, Zarski JP. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C. Effects of dose and duration. HEPATOLOGY 1996; 24: 778-789[Abstract].

11. Degos F, Daurat V, Chevret S, Gayno S, Bastie A, Riachi G, Ellouk AS, et al. Reenforced regimin of interferon alfa 2a reduces the incidence of cirrhosis in patients with chronic hepatitis C: a multicenter randomised trial. J Hepatol 1998;in press.

12. Fattovich G, Giustina G, Degos F, Tremolada F, Diaodati G, Almasio P, et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 1997; 112: 463-472[Abstract].

13. Poynard T, Bedossa P, Chevallier M, Mathurin P, Lemonnier C, Trepo C, Couzigou P, et al. A randomized trial of three 2b interferon regimens for long term treatment of patients with chronic non-A non-B hepatitis. N Eng J Med 1995; 332: 1457-1462[ [ Link previously at www.ncbi.nlm.nih.gov ]].

14. Davies G, Esteban-Mur R, Rustgi V, Hoefs J, Gordon S, Trepo C, et al. Retreatment of relapse after interferon for chronic hepatitis C: an international randomized controlled trial of interferon plus ribavirin vs interferon alone [Abstract]. HEPATOLOGY 1997; 26: 247A.

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