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Hepatitis B Surface Antibody General Clinical Tests

Test Name
Method
Hepatitis B Surface Antibody, Total Anti- HBs, HBsAb
Specimen
Requirements
Serum
Stable for 7 d at RT and indefinitely at 4° C or - 20°C.
Chemical Interfaces
In Vivo Effects
None Found

Ref. Range
Conventional
International Recommended Units
Negative

Limits of detection: 2-10 IU/L

Diagnostic Information With naturally occurring Hepatitis B infections, anti-HBs usually appears in the serum several weeks after disappearance of HBsAg. The presence of of anti-HBs generally means there is protection against Hepatitis B infection. However, convalescent anti-HBs mall fall below limits of detection. A qualitative finding of  >10 IU/L for post vaccine testing is the accepted concentration which confers protection.
Remarks Anti-HBs is now mainly used to assess efficacy of Hepatitis B vaccine but remains an adjunct test along with anti-HBc for determining whether subjects have immunity due to a naturally acquired infection or whether chronic Hepatitis B might exist in an HBsAg negative patient.

References:
Clinical Guide to Laboratory Tests, third edition.

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