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77 more hepatitis cases may trace to clinic, officials say
LAS VEGAS -- Seventy-seven more people that were treated at a Las Vegas outpatient clinic have been diagnosed with hepatitis C, health officials said. Authorities can't say for sure how the 77 people were infected, said Brian Labus, senior epidemiologist

77 more hepatitis cases may trace to clinic at center of Las Vegas outbreak, officials say
AM LAS VEGAS-Seventy-seven more people that were treated at a Las Vegas outpatient clinic accused of reusing syringes on thousands of people have been diagnosed with Hepatitis C, health officials said. Authorities cannot say for sure how the 77 people

77 more hepatitis cases may trace to clinic, officials say
Seventy-seven more people that were treated at a Las Vegas outpatient clinic have been diagnosed with hepatitis C, health officials said.Authorities can't say for sure how the 77 people were infected, said Brian Labus, senior epidemiologist with the


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Highly Effective Against HCV Genotype 1
When tested on people with Hepatitis C genotype 1, R7128 proved to be an effective addition to combination therapy after just four weeks' time. In addition to its anti-viral effect, polymerase inhibitor R7128 received good marks for safety and minimal...

Investigational Drug Beats Standard Therapy in Hepatitis C Study
A Phase IIa trial investigating triple combination therapy with PEGASYS, COPEGUS and Roche's investigational drug R1626, demonstrated a higher response rate than traditional combination therapy alone. While R1626's effectiveness and high barrier to resistance makes it a top Hepatitis C...

Hepatitis C Complications Helped by Maintenance Interferon
A four-year study confirms that low-dosage maintenance interferon therapy prevents disease progression in those with portal hypertension or cirrhosis from Hepatitis C....

GGT and 5'-NT

Gammaglutamyltransferase (GGT)

Located primarily in hepatocytes and to a lesser extent in a number of other organs

Highly sensitive to hepatocyte damage and cholestasis

Elevated in chronic alcohol consumption and binge drinking

Also elevated by extensive reparative processes, drugs (phenytoin and phenobarbital), obesity

Not elevated by bone disease, pregnancy, or childhood and adolescence

Used as a confirmatory test to indicate a hepatic origin for ALP elevation (GGT can be elevated in co-existing conditions, so interpret its results carefully and with consideration of the whole clinical picture)

5' -Nucleotidase

Provides confirmation for a hepatic origin for elevated ALP similar to GGT

More specific for the liver and for cholestasis than GGT (which is generally elevated with any type of hepatocellular injury)

Controversial as to whether GGT or 5'-NT provides the best confirmatory test; in the past, 5'-NT has been more difficult to perform and thus less generally available

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Updated 09 May 2008