|
GRADING & SCORING LIVER DAMAGE
Knodell Histological Activity Index
I. Periportal +/-bridging necrosis [Score]
•A. none [ 0]
•B. mild piecemeal necrosis [1]
•C. moderate piecemeal necrosis (involve less than 50% of the circumference
of most portal tracts) [3]
•D. marked piecemeal necrosis (involve more athan 50% of the circumference
of most portal tracts) [4]
•E. moderate piecemeal necrosis plus bridging necrosis plus bridging necrosis
[5]
•F. marked piecemeal necrosis plus bridging necrosis plus bridging necrosis
[6]
•G. multilobular necrosis [10]
•II. intralobular degeneration and focal necrosis
•A. none [0]
•B. mild (acidoplhilic bodies, balooning degeneration and/or scattered
foci of hepatocellular necrosis in less than 1/3 of lobules or nodules) [1]
•C. moderate (involvement of 1/3 ~ 2/3 of lobules or nodules) [3]
•D. marked (involvement of > 2/3 of lobules or nodules) [4]
•III. portal inflammation
•A. no portal inflammation [0]
•B. mild (sprinkling of inflammatory cells in less than 1/3 of portal tracts)
[1]
•C. moderate (increased inflammatory cells in 1/3 ~ 2/3 of portal tracts)
[3]
•D. marked (dense packing of inflammatory cells in > 2/3 of portal tracts)
[4]
•IV. fibrosis
•A. no fibrosis [0]
•B. fibrous portal expansion [1]
•C. bridging fibrosis (portal-portal or portal-central linkage) [3]
•D. cirrhosis [4]
|
