Hepatology 1981 Sep;1(5):431-435
Formulation and application of a numerical scoring system for assessing
histological activity in asymptomatic chronic active hepatitis.
Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW,
Wollman J
A Histology Activity
Index has been developed which generates a numerical score for liver
biopsy specimens obtained from patients with asymptomatic chronic active hepatitis.
Biopsies are graded in four categories: periportal necrosis, intralobular necrosis,
portal inflammation, and fibrosis. Under code, three pathologists and three
hepatologists evaluated 14 liver biopsy specimens obtained from five patients
with asymptomatic chronic active hepatitis. Good correlation was seen between
severity of liver biopsy lesions as judged by conventional histological descriptions
and Histology Activity Index scores. Significant differences in Histology Activity
Index score occurred in only 2 or 28 duplicate scorings of biopsy specimens
by two observers. This system provides definitive endpoints for statistical
analysis of serial changes in liver histology and offers an alternative to the
use of conventional pathological descriptions in following the natural history
and treatment responses of asymptomatic chronic active hepatitis.
PMID: 7308988, UI: 82074232
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