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Good News for Non-Responders to HCV Combination Therapy
A Phase 3 trial evaluating ZADAXIN® (thymalfasin) as a potential third component for Hepatitis C traditional combination therapy has just been completed. Although the data is currently being analyzed and won't be available until later in the year, the lead...
Purer, Less Costly Interferon for Hepatitis C and B Treatment
The Taiwan-based biopharmaceutical company PharmaEssentia Corp. is testing P1101, its third-generation PEG-interferon-alpha drug candidate. Because it is a longer-lasting, purer interferon that is less costly to produce, P1101 could enhance the treatment options for Hepatitis C and B....
New Technology May Help Treat Hepatitis
While pharmaceutical companies are racing to find safer, more effective treatments for viral Hepatitis C and B, physicists from Arizona have a unique perspective on accomplishing the same goal. Learn how these scientists believe the virus could be rendered harmelss...
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Basic Histopath of the liver
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Normal Liver
Blood flows into the liver via the hepatic veins (in the portal
triad) and out of the liver via the central veins in the lobules.
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Alcoholic Cirrhosis
Alcohol coming from the gut first makes contact with the hepatocytes
nearest the portal triad. These liver cells, will be affected first
by the toxicity of alcohol. The fibrosis (in blue in this trichrome
stain) is coming "from the outside in" with respect to the lobule.
At this stage, the lobules themselves are spared.
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Congestive Cirrhosis
As the heart fails, blood is backed up in the venous system. The
central veins (arrow), you recall, eventually empty into the inferior
vena cava. Since the heart is "backed up," you can see the red blood
pooling near the central vein of some lobules. In this process,
fibrosis occurs "from the inside out."
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Hepatitis B
The Hepatitis B virus is extremely contagious and causes widespread
necrosis of the liver. The destruction encompasses both the lobules
and the interstitium making this tissue almost unrecognizable.
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