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Lower CD4 Count Linked to Increased Risk of Liver Cancer in HIV Positive People, Especially Those with Hepatitis B Coinfection
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Volunteers Needed for Hepatitis B Study
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Viral Hepatitis C support group to begin meeting
AUBURN, CALIF Placer County Health and Human Services will begin hosting a hepatitis C support group for anyone who wants to know more about the disease and its treatment. The confidential group is offered at no cost, is open to the public and will meet

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The Hepatitis Vaccine That Does Double Duty
People who have Hepatitis C and have not been vaccinated against Hepatitis A or Hepatitis B could benefit from the combined hepatitis vaccine....

Medical Spas May Pose Hepatitis Risk
Since medical spas are offering more treatments involving the use of needles, the potential for Hepatitis C transmission is rising. Learn about some of the spa treatment techniques that pose hepatitis transmission dangers, as well as five ways to increase...

Hepatitis B Treatment May Reduce Pancreatic Cancer Risk
While several theories are attempting to explain the connection, scientists are unsure why those with Hepatitis B appear to have a 2 1/2 fold increase in risk for developing pancreatic cancer. Once the link is understood, Hepatitis B treatment may...

Damage Scores for Liver Biopsy

Less Than Less Than

Greater Than More Than

HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)

 
Periportal ± Bridging Necrosis Score Intralobular Degeneration and Focal Necrosis Score Portal Inflammation Score Fibrosis Score
None 0 None 0 No portal inflammation 0 No fibrosis 0
Mild piecemeal necrosis 1 Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules) 1 Mild (sprinkling of inflammatory cells in Less Than 1/3 of portal tracts) 1 Fibrous portal expansion 1
Moderate piecemeal necrosis (involves      Less Than 50% of the circumference of most portal tracts) 3 Moderate (involvement of 1/3-2/3 of lobules or nodules) 3 Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts) 3 Bridging Fibrosis (portal-portal or portal-central linkage) 3
Marked piecemeal necrosis (involves     Greater Than 50% of the circumference of most portal tracts) 4 Marked (involvement of Greater Than 2/3 of lobules or nodules) 4 Marked (dense packing of inflammatory cells in Greater Than 2/3 of portal tracts) 4 Cirrhosis 4
Moderate piecemeal necrosis plus bridging necrosis 5

ReferenceKnodell RG, et al. 
Marked piecemeal necrosis plus bridging necrosis 6
Multilobular necrosis 10
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Updated 11 Oct 2008