Semin Cutan Med Surg 1997 Dec;16(4):273-277
Oral lichen planus: epidemiology, clinical characteristics, and associated
diseases
Lozada-Nur F, Miranda C
Oral lichen planus (OLP) is a chronic inflammatory disease, the cause of which
remains unknown. In the last few years, significant advances have been made in
understanding the mechanisms involved in the pathogenesis of the disease. Data
on HLA markers for OLP vary depending on the population studied. OLP is a disease
primarily of adults (50 to 55 years of age) and predominantly affects women. Any
site in the oral cavity may be involved, but the buccal mucosa and gingiva are
the most common sites. OLP can have different clinical presentations, with the
reticular, erosive, and atrophic types being the most commonly reported. OLP has
been reported to be associated with different medical conditions such as diabetes,
hepatitis C infection, liver disease, and oral cancer. With the exception of oral
cancer, there are not good data to support such associations. The question that
remains to be answered is why we see a higher prevalence of oral carcinoma in
patients with OLP. The relative prevalence from our series was 1.2%. Therefore,
we believe patients with OLP have a higher risk for oral cancer and should be
monitored for malignant transformation once a year.
PMID: 9421218, UI: 98081571
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