Hepatitis Central

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Adding ribavirin to interferon alpha -2b for chronic hepatitis C infection increased virological response and nausea

Interferon alpha -2b plus ribavirin (combination therapy) v interferon alpha -2b alone (monotherapy) at 48 weeks in chronic hepatitis C virus infection*
Outcome
Combination therapy
Mono- therapy
RBI (95% CI)
NNT (CI)
Virological response 36% 18% 100% (2 to 302) 6 (3 to 193)
Outcomes Combination therapy Mono- therapy RRI (CI) NNH (CI)
Dose reduction or treatment withdrawal 32% 12% 167% (19 to 520) 5 (3 to 27)
Nausea 34% 12% 183% (27 to 555) 5 (3 to 18)
* RBI=proportional increase in rates of good outcomes between combination therapy and monotherapy groups; NNT=number of patients who must receive combination therapy to achieve 1 additional good outcome; RRI=proportional increase in rates of bad outcomes between combination therapy and monotherapy groups; NNH=number of patients who, if they received combination therapy, would lead to 1 additional person being harmed.

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