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table  2.   Kinetic Data of HCV and ALT and AST Turnover in Patients With Chronic Hepatitis C Responding to Treatment With rIFN- Alone or in Combination With Ribavirin (14 mg/kg of body weight)
Kinetic Parameter 3 × 3 MU rIFN--= SRC="b_alpha.gif"> (N = 10) 3 × 6 MU rIFN--= SRC="b_alpha.gif"> (N = 10) 3 × 6 MU rIFN--= SRC="b_alpha.gif"> + ribavirin (N = 10)
HCV RNA
   B0RNA (106/mL) 7.19 ± 14.01 7.13 ± 6.76 9.49 ± 10.99
  t1/2 (ln 2/k1) (d) 2.28 ± 1.17 2.54 ± 2.10 1.99 ± 1.70
  t1/2 (ln 2/k2) (d) 0.67 ± 0.36 0.23 ± 0.15 0.18 ± 0.19
ALT
   B0ALT (U/L) 83.1 ± 56.1 84.0 ± 49.7 58.7 ± 28.8
  BALT (U/L) 8.9 ± 2.5 14.6 ± 7.1 9.7 ± 3.4
  t1/2 (ln 2/k3) (d) 4.3 ± 4.4 3.2 ± 2.5 7.8 ± 9.4
  t1/2 (ln 2/k4) (d) 3.5 ± 1.5 3.7 ± 2.1 4.3 ± 3.4
AST
   B0AST (U/L) 31.3 ± 15.5 37.9 ± 17.9 29.1 ± 10.4
   BAST (U/L) 8.8 ± 1.8 12.3 ± 4.6 10.5 ± 2.4
  t1/2 (ln 2/k3) (d) 4.1 ± 5.0 2.7 ± 3.0 5.2 ± 5.9
  t1/2 (ln 2/k4) (d) 3.4 ± 2.0 3.4 ± 1.8 3.3 ± 3.4
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