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Hepatitis C Virus Dynamics In Vivo:
Effect of Ribavirin and Interferon Alfa on Viral
Turnover
Fig. 1. Serum HCV RNA and transaminase determinations in
patients with chronic hepatitis C responding to antiviral therapy.
All patients responding to treatment with (A) 3 × 3 MU
rIFN- per week, (B) 3
× 6 MU rIFN- per
week, and (C) 3 × 6 MU rIFN- per week plus ribavirin (14 mg/kg/d orally). Therapy
was initiated at day 0 and continued throughout the study. Observed
HCV RNA (×), ALT ( ), and AST levels ( ) are indicated. Undetectable serum HCV RNA data are not
shown. Lines are calculated from the best-fitting individual
parameter sets. The lower edge of each panel indicates the
analytical sensitivity. The normal ranges for ALT and AST are 4 to
22 and 4 to 20 U/L, respectively.
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Copyright © 1998 by the American Association for the Study
of Liver Diseases.
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