Treatment of Hep C with Ribavirin
1996, 11 Suppl 4:, 62-4
ABSTRACT
Author: Trepo C; Bailly F Bizollon
T Hepatology Department Hôtel-Dieu, Lyon, France.
Ribavirin is a nucleoside analogue with anti-viral activity against a number
of DNA and RNA viruses. That molecule is administered per os and its most frequent
adverse effect is haemolysis, moderate in most cases. Used alone, ribavirin
normalized liver enzyme concentrations in 45% of patients while viraemia is
not significantly modified. Histological improvement is observed in responder
patients. The most interesting results have been obtained by associating ribavirin
with interferon. In patients who have never been treated, a six-month course
of ribavirin-interferon association produced a lasting and total response in
47% of patients versus 25% in patients treated with interferon alone. In relapsers,
this bi- therapy produced total and prolonged response in more than 40% of cases
and in 20% of non- responder patients. Lastly, that association appears promising
in treating Hepatitis C reinfection after liver transplantation.
9707645
Source: Nephrol Dial Transplant
1996, 11 Suppl 4:, 62-4
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