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High Incidence of Allograft Cirrhosis in Hepatitis C Virus Genotype 1b Infection Following Transplantation: Relationship With Rejection Episodes

table  1.   Histological Grading and Staging at Last Follow-up in Patients With Hepatitis C After Liver Transplantation
n (%) Mean
Follow-up
± SD (mo)
Grade (activity)*
  Minimal 12 (15.1) 25 ± 19
  Mild 16 (20.2) 35 ± 19
  Moderate 32 (40.5) 31 ± 15
  Severe 19 (24.1) 32 ± 16
Stage (fibrosis)dagger
  None 29 (35.8) 29.8 ± 16.5
  Fibrous portal expansion 26 (32.1) 32.8 ± 18.1
  Bridging fibrosis 14 (17.3) 34.3 ± 17.5
  Cirrhosis 12 (14.8) 30 ± 14
* Determined by combining the HAI (Knodell) scores for periportal necrosis (0-6), lobular degeneration and necrosis (0-4), and portal inflammation (0-4), and defined as follows: 1-2, minimal; 3-6, mild; 7-10, moderate; 11-14, severe.
dagger Defined according to the HAI (Knodell) fibrosis score: 0, none; 1, fibrous portal expansion; 3, bridging fibrosis; 4, cirrhosis.

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