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High Incidence of Allograft Cirrhosis in Hepatitis C Virus
Genotype 1b Infection Following Transplantation: Relationship With
Rejection Episodes
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table 1. Histological Grading and
Staging at Last Follow-up in Patients With Hepatitis C After Liver
Transplantation
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n (%) |
Mean
Follow-up
± SD (mo) |
|
| Grade (activity)* |
| Minimal |
12 (15.1) |
25 ± 19 |
| Mild |
16 (20.2) |
35 ± 19 |
| Moderate |
32 (40.5) |
31 ± 15 |
| Severe |
19 (24.1) |
32 ± 16 |
Stage (fibrosis) |
| None |
29 (35.8) |
29.8 ± 16.5 |
| Fibrous portal expansion |
26 (32.1) |
32.8 ± 18.1 |
| Bridging fibrosis |
14 (17.3) |
34.3 ± 17.5 |
| Cirrhosis |
12 (14.8) |
30 ± 14 |
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* Determined by
combining the HAI (Knodell) scores for periportal necrosis (0-6),
lobular degeneration and necrosis (0-4), and portal inflammation
(0-4), and defined as follows: 1-2, minimal; 3-6, mild;
7-10, moderate; 11-14, severe.
Defined according to the
HAI (Knodell) fibrosis score: 0, none; 1, fibrous portal
expansion; 3, bridging fibrosis; 4, cirrhosis. |
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