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High Incidence of Allograft Cirrhosis in Hepatitis C Virus Genotype 1b Infection Following Transplantation: Relationship With Rejection Episodes

table  3.   Factors Associated With the Development of Graft Cirrhosis in HCV-Positive Patients Following Liver Transplantation
Patients With
Cirrhosis
(n = 12) 		Patients
Without
Cirrhosis
(n = 69) 		P
Age 53.2 ± 10.8 54.7 ± 7.4  .53
Female sex, n (%) 6 (50) 19 (27.5) .12
Pre-OLT HCC, n (%) 2 (17) 17 (25) .55
Duration of histologic follow-up (mo) 30 ± 14 31.8 ± 17.2 .32
Patients with rejection episodes, n (%) 10 (83) 33 (48) .02
Patients treated for rejection, n (%) 9 (75) 29 (42) .03
Patients receiving OKT3 for SRR, n (%) 2 (17) 3 (4) .32
Patients with early rejection, n (%)* 9 (75) 28 (41) .03
Patients treated for early rejection, n (%) 8 (67) 25 (36) .05
Patients with late rejection, n (%)* 5 (42) 8 (12) .009
Patients treated for late rejection, n (%) 4 (33) 8 (12) .05
Patients with mild rejection, n (%) 5 (42) 19 (27) .32
Patients with moderate rejection, n (%) 4 (33) 15 (22) .38
Patients with severe rejection, n (%) 3 (25) 1 (1) .009
Number of rejection episodes 1.2 ± 0.7 0.5 ± 0.6 .001
Number of MP boluses   3 ± 2.2 1.5 ± 2.1 .03
Abbreviations: SRR, steroid-resistant rejection; MP, methylprednisolone.
* Early rejection was defined as rejection occurring within the first 4 weeks following transplantation, while late rejection refers to rejection episodes occurring after the first month.

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