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Extended Drug Therapy for Hepatitis Is Challenged
Patients who do not initially respond to standard drug therapy for treatment of hepatitis C are unlikely to respond to long-term maintenance therapy as well, according to a new study. Yet many patients who do not at first respond to drugs are placed on

Gilead Sciences, Inc. (GILD) Release: Data Demonstrating Significant Efficacy of Viread(R) in Treating Chronic Hepatitis B Published in New England Journal of Medicine
FOSTER CITY, Calif.--(BUSINESS WIRE)-- (Nasdaq: GILD) today announced the publication of detailed 48-week data from two Phase III pivotal clinical trials evaluating the safety and efficacy of its once-daily Viread (tenofovir disoproxil fumarate) for the

Interferon as long-term treatment for hepatitis C not effective
Results of the 3-year study, called the HALT-C (Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis) Trial, appear in today's issue of . The researchers found no difference in the rate of progression of liver disease among patients who received

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Hep C Study Reveals Taribavirin a Good Alternative to Ribavirin
At the end of a 48-week, Phase IIb study, taribavirin shows similar effectiveness as ribavirin in reducing Hepatitis C viral load. However, participants taking taribavirin had a significantly lower rate of anemia....

Schering-Plough Developing Potent Protease Inhibitor for Hepatitis C
An ongoing Phase IIa study on Schering-Plough's next generation Hepatitis C protease inhibitor is encouraging. According to the company, SCH 900518 is 10 times more potent than other medications in this class and is active against highly resistant Hepatitis C...

New Drug Finds Viral Hiding Spots
A new, experimental drug helps the immune system locate a virus by flagging cells that have turned inside out. Hepatitis C is among the viruses that could benefit from Bavituximab's unique strategy of exposing a virus in hiding....

Hepatitis B and C: An Overview

References

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3. Davies SE, Portmann BC, O'Grady JG, Aldis PM, Chaggar K, Alexander G, et al. Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis. Hepatology 1991;13:150-157[ Abstract].

4. Thung SN, Gerber MA. Acute hepatitis versus cellular (acute) liver allograft rejection (chap 37). Cellular (acute) liver allograft rejection versus chronic liver allograft rejection (chap 39). In: Epstein JI (ed). Differential diagnosis in pathology liver disorders. New York: Igaku-Shoin Medical Publishers, Inc., 1995:38-39.

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11. McGory RW, Ishitani MB, Oliveira WM, Stevenson WC, McCullough CS, Dickson RC, et al. Improved outcome of orthotopic liver transplantation for chronic hepatitis B cirrhosis with aggressive passive immunization. Transplantation 1996;61:1358-1364[ [ Link previously at www.ncbi.nlm.nih.gov ]].

12. Shouval D, Ilan Y. Transplantation of hepatitis B immune lymphocytes as means for adoptive transfer of immunity to hepatitis B virus. J Hepatol 1995;23:98-101[ [ Link previously at www.ncbi.nlm.nih.gov ]].

13. Gretch DR, Bacchi CE, Corey L, DeLa Rosa C, Lesniewski RR, Kowdley K, et al. Persistent hepatitis C virus infection after liver transplantation: Clinical and virological features. Hepatology 1995;22:1-9[ Abstract].

14. Chazouilleres O, Kim M, Combs C, Ferrell L, Bacchetti P, Roberts J, et al. Quantitation of hepatitis C virus RNA in liver transplant recipients. Gastroenterology 1994;106:994-999[ Abstract].

15. Schluger LK, Sheiner PA, Thung SN, Lau JYN, Min A, Wolf DC, et al. Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation. Hepatology 1996;23:971-976[ Abstract].

16. Mueller AR, Platz K-P, Bechstein W-O, Blumhardt G, Lobeck H, Hop U, Neuhaus P. Increased rejection after liver transplantation in FK 506-treated patients is associated with viral hepatitis C disease. Transplant Proc 1994;26:3637-3639[ [ Link previously at www.ncbi.nlm.nih.gov ]].

17. Min AD, Bodenheimer HB. Does interferon precipitate rejection of liver allograft? Hepatology 1995;22:1333-1335[ [ Link previously at www.ncbi.nlm.nih.gov ]].

18. Wright HI, Gavaler JS, Van Thiel DH. Preliminary experience with -2b-interferon therapy of viral hepatitis in liver allograft recipients. Transplantation 1992;53:121-124[ [ Link previously at www.ncbi.nlm.nih.gov ]].

19. Wright TL, Combs C, Kim M, Ferrell L, Bacchetti P, Ascher N, et al. Interferon- therapy for hepatitis C virus infection after liver transplantation. Hepatology 1994;20:773-779[ Abstract].

20. Féray C, Samuel D, Gigou M, Paradis V, David MF, Lemonnier C, et al. An open trial of interferon alfa recombinant for hepatitis C after liver transplantation: Antiviral effects and risk of rejection. Hepatology 1995;22:1084-1089[ Abstract].

21. Vargas V, Charco R, Castells L, Esteban R, Margarit C. Alpha-interferon for acute hepatitis C in liver transplant patients. Transplant Proc 1995;27:1222-1223[ [ Link previously at www.ncbi.nlm.nih.gov ]].

22. Bodenheimer HC, Lindsay KL, Davis GL, Lewis JH, Thung SN, Seeff LB. Tolerance and efficacy of oral ribavirin treatment of chronic hepatitis C: A multicenter trial. Hepatology 1997;26:473-477[ Abstract].

23. Bizollon T, Palazzo U, Ducerf C, Chevallier M, Elliott M, Baulieux J, et al. Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation. Hepatology 1997;26:500-504[ Abstract].

24. McHutchison JG. Ribavirin and interferon for recurrent posttransplantation HCV infection: To treat or not to treat? Hepatology 1997;26:505-506[ [ Link previously at www.ncbi.nlm.nih.gov ]].

25. Wright TL, Donegan E, Hsu HH, Ferrell L, Lake JR, Kim M, et al. Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology 1992;103:317-322[ Abstract].

26. Sheiner PA, Schluger LK, Emre S, Thung SN, Lau JYN, Guy SR, et al. Retransplantation for recurrent hepatitis C. Liver Transplant Surg 1997;3:130-136[Abstract].

Liver Transplantation and Surgery, Vol 4, No 5, Suppl 1 (September), 1998: pp S65-S67

1074-3022/98/0405-1009$3.00/0

Copyright © 1998 by the American Association for the Study of Liver Diseases

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