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Promising Partnership in Treating Hepatitis C

October 24, 2006

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Two leading companies are merging in an effort to accelerate Hepatitis C treatments. The goal of this collaboration is to further the development of Hepatitis C protease inhibitors.

Roche and InterMune to develop hepatitis C products

Pharmaceutical Business Review Online
By Victoria Harrison

Roche and InterMune have signed an agreement to develop and commercialize candidates from InterMune's hepatitis C protease inhibitor program

The agreement includes InterMune's lead compound ITMN-191, which is expected to enter clinical trials before the end of the year. The companies will also collaborate on a research program of novel second-generation hepatitis C protease inhibitors.

"We believe this partnership will help accelerate the development of ITMN-191 and future second-generation protease inhibitors," said Dan Welch, CEO of InterMune.

Roche will exclusively license ITMN-191 and will have the right to exclusively license further hepatitis C protease inhibitor development candidates resulting from the research collaboration.

InterMune will conduct phase I studies of ITMN-191, and thereafter Roche will lead clinical development and commercialization. Upon closing, InterMune will receive from Roche an upfront payment of $60 million. InterMune could potentially receive up to $470 million in milestones as a result of the deal. The companies will co-commercialize the product in the US.

The economic terms for ITMN-191 could also apply to additional compounds that InterMune and Roche develop.

The transaction will close following the expiration or early termination of an antitrust regulatory waiting period.

Posted by Editors at October 24, 2006 7:30 AM

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