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Antioxidant Shown to Block Hepatitis C Replication

January 8, 2010

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Researchers recently learned that Quercetin, a popular antioxidant, inhibits the synthesis of proteins needed for Hepatitis C replication.

Natural compound blocks hepatitis C infection

Finding may lead to a new treatment

January 4, 2010: Researchers have identified two cellular proteins that are important factors in hepatitis C virus infection, a finding that may result in the approval of new and less toxic treatments for the disease, which can lead to liver cancer and cirrhosis.

An estimated 270 to 300 million people worldwide are infected with hepatitis C and the conventional treatments - interferon and ribavirin - can have significant side effects. A new drug targeting cellular proteins rather than viral proteins would be a valuable addition to the treatment arsenal, said Samuel French, an assistant professor of pathology and senior author of the study.

French and his team set out to identify the cellular factors involved in hepatitis C replication and, using mass spectrometry, found that heat shock proteins (HSPs) 40 and 70 were important for viral infection. HSP 70 was previously known to be involved, but HSP 40 was linked for the first time to hepatitis C infection, French said. They further showed that the natural compound Quercetin, which inhibits the synthesis of these proteins, significantly inhibits viral infection in tissue culture.

Continue reading the entire article:
http://www.eurekalert.org/pub_releases/2010-01/uoc--ncb010410.php

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles

Posted by Editors at January 8, 2010 2:56 PM

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