Altered Mice Offer Ideal Liver Disease Drug Testing Model
Solving the ongoing challenge of how to test potential liver disease drugs before experimenting on humans, Salk Institute researchers have perfected a system where medications can be tested in mice with mostly human livers.
Mouse With Human Liver: New Model for Treatment of Liver Disease
ScienceDaily (Feb. 23, 2010) -- How do you study-and try to cure in the laboratory-an infection that only humans can get? A team led by Salk Institute researchers does it by generating a mouse with an almost completely human liver. This "humanized" mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria.
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